Epstein-Barr virus (EBV)-related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 ± 3.1 years, and the male-to-female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher (P < 0.001) in children with head and neck disease. Tumor cells had MYC translocation (96%) and were CD20+/CD10+/MYC+/BCL2−. MUM1/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent (P < 0.007) in head and neck disease (12/42; 29%). EBV-encoded RNA was positive in 100 of 125 (80%) BL cases.

Burkitt lymphoma in Iraqi children. A distinctive form of sporadic disease with high incidence of EBV+cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation / Uccini, S; Al-Jadiry, Mf; Cippitelli, C; Talerico, C; Scarpino, S; Al-Darraji, Af; Al-Badri, Saf; Alsaadawi, Ar; Al-Hadad, Sa; Ruco, L. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5009. - 65:12(2018), p. e27399. [10.1002/pbc.27399]

Burkitt lymphoma in Iraqi children. A distinctive form of sporadic disease with high incidence of EBV+cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation

Uccini S;Cippitelli C;Scarpino S;Ruco L
2018

Abstract

Epstein-Barr virus (EBV)-related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 ± 3.1 years, and the male-to-female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher (P < 0.001) in children with head and neck disease. Tumor cells had MYC translocation (96%) and were CD20+/CD10+/MYC+/BCL2−. MUM1/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent (P < 0.007) in head and neck disease (12/42; 29%). EBV-encoded RNA was positive in 100 of 125 (80%) BL cases.
Burkitt lymphoma; Epstein–Barr virus; MUM1/IRF4; pediatric oncology; pediatrics, perinatology and child health; hematology; oncology
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Burkitt lymphoma in Iraqi children. A distinctive form of sporadic disease with high incidence of EBV+cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation / Uccini, S; Al-Jadiry, Mf; Cippitelli, C; Talerico, C; Scarpino, S; Al-Darraji, Af; Al-Badri, Saf; Alsaadawi, Ar; Al-Hadad, Sa; Ruco, L. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5009. - 65:12(2018), p. e27399. [10.1002/pbc.27399]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1168393
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