To investigate the role of protein charge in early diabetic proteinuria, the clearance of proteins differing in charge and/or size (anionic and cationic Igs, albumin) was evaluated in 98 insulin-dependent (type I) diabetic patients selected as a representative sample of the 418 patients attending our clinics. Of the patients, 12.9% were microalbuminuric and 4.8% were macroalbuminuric. Anionic and total IgG clearances were significantly increased in 30.6 and 12.2% of patients and were correlated with duration of disease. Anionic IgG4 clearances were increased in patients (9.2%) with normal IgG excretion, suggesting that charge-selectivity impairment is responsible for protein loss. Anionic Ig clearances were also higher in some patients (14.3%) with normal albumin clearance, probably as a result of different glomerular filtration and/or tubular reabsorption. The anionic-cationic IgG clearance ratio tended to increase in parallel with albumin clearance, but once above macroalbuminuric levels, it tended to fall again, indicating the concomitant presence of size-selectivity loss. The anionic IgG clearance and the anionic-cationic IgG ratio, in addition to albumin excretion, may be valuable in assessing early kidney protein charge-selectivity impairment and better characterizing normoalbuminuric patients and those in the preclinical stage of diabetic nephropathy.

Charge selectivity of proteinuria in type 1 diabetes explored by immunoglobulin subclass clearance / Pietravalle, P; Morano, Susanna; Cristina, G; DE ROSSI, Mg; Mariani, G; Cotroneo, P; Ghirlanda, G; Clementi, A; Andreani, Domenico; DI MARIO, Umberto. - In: DIABETES. - ISSN 0012-1797. - 40:(1991), pp. 1685-1690. [10.2337/diabetes.40.12.1685]

Charge selectivity of proteinuria in type 1 diabetes explored by immunoglobulin subclass clearance

MORANO, Susanna;ANDREANI, Domenico;DI MARIO, Umberto
1991

Abstract

To investigate the role of protein charge in early diabetic proteinuria, the clearance of proteins differing in charge and/or size (anionic and cationic Igs, albumin) was evaluated in 98 insulin-dependent (type I) diabetic patients selected as a representative sample of the 418 patients attending our clinics. Of the patients, 12.9% were microalbuminuric and 4.8% were macroalbuminuric. Anionic and total IgG clearances were significantly increased in 30.6 and 12.2% of patients and were correlated with duration of disease. Anionic IgG4 clearances were increased in patients (9.2%) with normal IgG excretion, suggesting that charge-selectivity impairment is responsible for protein loss. Anionic Ig clearances were also higher in some patients (14.3%) with normal albumin clearance, probably as a result of different glomerular filtration and/or tubular reabsorption. The anionic-cationic IgG clearance ratio tended to increase in parallel with albumin clearance, but once above macroalbuminuric levels, it tended to fall again, indicating the concomitant presence of size-selectivity loss. The anionic IgG clearance and the anionic-cationic IgG ratio, in addition to albumin excretion, may be valuable in assessing early kidney protein charge-selectivity impairment and better characterizing normoalbuminuric patients and those in the preclinical stage of diabetic nephropathy.
1991
01 Pubblicazione su rivista::01a Articolo in rivista
Charge selectivity of proteinuria in type 1 diabetes explored by immunoglobulin subclass clearance / Pietravalle, P; Morano, Susanna; Cristina, G; DE ROSSI, Mg; Mariani, G; Cotroneo, P; Ghirlanda, G; Clementi, A; Andreani, Domenico; DI MARIO, Umberto. - In: DIABETES. - ISSN 0012-1797. - 40:(1991), pp. 1685-1690. [10.2337/diabetes.40.12.1685]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/116800
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