Thanks to the widespread use of amniocentesis, glucose, insulin, and C peptide have often been measured in amniotic fluid (AF) during late gestation, but little is known about their concentrations during early pregnancy. To better understand early fetal β-cell function under normal conditions and in the presence of maternal diabetes, we measured glucose, insulin, and C peptide in the AF collected during weeks 15-22 in 77 healthy and 9 diabetic women undergoing amniocentesis for clinical indications and compared the results with those obtained during late pregnancy (weeks 34- 36). The AF C peptide concentration was higher in diabetic women (102 ± 53 vs. 38 ± 2 pmol/L), in the women with a family history of diabetes (41 ± 6 vs. 35 ± 2 pmol/L), after the 19th week of gestation (46 ± 5 vs. 35 ± 2 pmol/L; in the presence of lower glucose concentrations), and in the presence of maternal plasma glucose levels greater than 5.56 mmol/L (42 ± 3.5 vs. 34 ± 2 pmol/L). The comparison between early and late gestation showed decreasing glucose and increasing C peptide concentrations in both healthy and diabetic women (in the latter, C peptide values were always 3 times higher), whereas the insulin concentration was increased in late gestation only in diabetic women. The AF C peptide/insulin molar ratio increased throughout pregnancy in both healthy (from 0.97 ± 0.06 to 4.3 ± 1.2) and diabetic (from 2.9 ± 1.1 to 13.2 ± 1.6) women. These parallel changes suggest that the fetal clearance and/or degradation of insulin and C peptide may greatly change during both normal and diabetic gestation.

AMNIOTIC FLUID INSULIN AND C-PEPTIDE IN EARLY PREGNANCY OF DIABETIC AND NON-DIABETIC WOMEN / Fallucca, F; Sciullo, E; Napoli, Angela; Cardellini, G; Maldonato, A.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 81:(1995), pp. 137-139. [10.1210/jc.81.1.137]

AMNIOTIC FLUID INSULIN AND C-PEPTIDE IN EARLY PREGNANCY OF DIABETIC AND NON-DIABETIC WOMEN.

NAPOLI, Angela;
1995

Abstract

Thanks to the widespread use of amniocentesis, glucose, insulin, and C peptide have often been measured in amniotic fluid (AF) during late gestation, but little is known about their concentrations during early pregnancy. To better understand early fetal β-cell function under normal conditions and in the presence of maternal diabetes, we measured glucose, insulin, and C peptide in the AF collected during weeks 15-22 in 77 healthy and 9 diabetic women undergoing amniocentesis for clinical indications and compared the results with those obtained during late pregnancy (weeks 34- 36). The AF C peptide concentration was higher in diabetic women (102 ± 53 vs. 38 ± 2 pmol/L), in the women with a family history of diabetes (41 ± 6 vs. 35 ± 2 pmol/L), after the 19th week of gestation (46 ± 5 vs. 35 ± 2 pmol/L; in the presence of lower glucose concentrations), and in the presence of maternal plasma glucose levels greater than 5.56 mmol/L (42 ± 3.5 vs. 34 ± 2 pmol/L). The comparison between early and late gestation showed decreasing glucose and increasing C peptide concentrations in both healthy and diabetic women (in the latter, C peptide values were always 3 times higher), whereas the insulin concentration was increased in late gestation only in diabetic women. The AF C peptide/insulin molar ratio increased throughout pregnancy in both healthy (from 0.97 ± 0.06 to 4.3 ± 1.2) and diabetic (from 2.9 ± 1.1 to 13.2 ± 1.6) women. These parallel changes suggest that the fetal clearance and/or degradation of insulin and C peptide may greatly change during both normal and diabetic gestation.
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AMNIOTIC FLUID INSULIN AND C-PEPTIDE IN EARLY PREGNANCY OF DIABETIC AND NON-DIABETIC WOMEN / Fallucca, F; Sciullo, E; Napoli, Angela; Cardellini, G; Maldonato, A.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 81:(1995), pp. 137-139. [10.1210/jc.81.1.137]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/116559
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