The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions. This review focuses on how themultilayered crosstalk between different Notches and NF-kB subunits may converge on Foxp3 gene regulation and orchestrate CD4+ regulatory T (Treg) cell function, particularly in a tumor microenvironment. Notably, Treg cells may play a pivotal role in the inhibition of antitumor immune responses, possibly promoting tumor growth. A future challenge is represented by further dissection of both Notch and NF-kB pathways and consequences of their intersection in tumor-associated Treg biology. This may shed light on themolecularmechanisms regulating Treg cell expansion andmigration to peripheral lymphoid organs thought to facilitate tumor development and still to be explored. In so doing, new opportunities for combined and/or more selective therapeutic Q25 approaches to improve anticancer immunity may be found.

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer / Ferrandino, Francesca; Grazioli, Paola; Bellavia, Diana; Campese, Antonio Francesco; Screpanti, Isabella; Felli, MARIA PIA. - STAMPA. - 9:(2018), pp. 1-9. [10.3389/fimmu.2018.02165]

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer

Francesca Ferrandino
Primo
Writing – Original Draft Preparation
;
Paola Grazioli;Diana Bellavia;Antonio Francesco Campese;Isabella Screpanti
;
Maria Pia Felli
Ultimo
Writing – Review & Editing
2018

Abstract

The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions. This review focuses on how themultilayered crosstalk between different Notches and NF-kB subunits may converge on Foxp3 gene regulation and orchestrate CD4+ regulatory T (Treg) cell function, particularly in a tumor microenvironment. Notably, Treg cells may play a pivotal role in the inhibition of antitumor immune responses, possibly promoting tumor growth. A future challenge is represented by further dissection of both Notch and NF-kB pathways and consequences of their intersection in tumor-associated Treg biology. This may shed light on themolecularmechanisms regulating Treg cell expansion andmigration to peripheral lymphoid organs thought to facilitate tumor development and still to be explored. In so doing, new opportunities for combined and/or more selective therapeutic Q25 approaches to improve anticancer immunity may be found.
2018
Notch, NF-kB, regulatory T-cell, Foxp3, cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer / Ferrandino, Francesca; Grazioli, Paola; Bellavia, Diana; Campese, Antonio Francesco; Screpanti, Isabella; Felli, MARIA PIA. - STAMPA. - 9:(2018), pp. 1-9. [10.3389/fimmu.2018.02165]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1165511
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