Galanin (Gal) is a neuropeptide with supposed neurotrophic-like action. In the present study, expression of Gal has been investigated in the core and peri-infarct zone at 1, 4, 24 and 72 h after middle cerebral artery occlusion (MCAo) in the rat. Three days after MCAo a small but consistent number of morphological intact Gal-positive neuronal cells were observed in the peri-infarct zone. Gal-positive cells were barely detectable in the infarct and peri-infarct zone at 24 h. No Gal immunopositive cells were detected in brain subjected to I and 4 h of ischemia. Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions. (C) 2005 Elsevier B.V. All rights reserved.
Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat / Manuela De, Michele; Giuseppe, Sancesario; Toni, Danilo; Alessandro, Ciuffoli; Giorgio, Bernardi; Sette, Giuliano. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - ELETTRONICO. - 134:1(2006), pp. 38-45. [10.1016/j.regpep.2005.12.002]
Specific expression of galanin in the peri-infarct zone after permanent focal cerebral ischemia in the rat
TONI, Danilo;SETTE, Giuliano
2006
Abstract
Galanin (Gal) is a neuropeptide with supposed neurotrophic-like action. In the present study, expression of Gal has been investigated in the core and peri-infarct zone at 1, 4, 24 and 72 h after middle cerebral artery occlusion (MCAo) in the rat. Three days after MCAo a small but consistent number of morphological intact Gal-positive neuronal cells were observed in the peri-infarct zone. Gal-positive cells were barely detectable in the infarct and peri-infarct zone at 24 h. No Gal immunopositive cells were detected in brain subjected to I and 4 h of ischemia. Gal immunoreactivity was also detected in myelinated fibers 4 and 24 h after focal ischemia. Gal may be a peptide with neurotrophic and plasticity functions under stress conditions. (C) 2005 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
