Recently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development.
High occurence of DRB1 11 in chronic lymphocytic leukaemia families / Ioannis, Theodorou; Laurent, Abel; Mauro, Francesca Romana; Brigitte, Duprey; Christian, Magnac; Beatrice Payelle, Brogard; Frederic, Davi; Guillaume, Dighiero. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 119:3(2002), pp. 713-715. [10.1046/j.1365-2141.2002.03926.x]
High occurence of DRB1 11 in chronic lymphocytic leukaemia families
MAURO, Francesca Romana;
2002
Abstract
Recently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
