Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We have demonstrated that allograft recipients who remain rejection-free display allospecific T-suppressor cells (Ts). Ts express the CD8(+) CD28(-) phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the upregulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.

Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells / Cortesini, Raffaello; Elvira Renna, Molajoni; Cinti, Paola; Pretagostini, Renzo; Eric, Ho; Paola, Rossi; Nsf, Cortesini. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 63:11(2002), pp. 1010-1018. [10.1016/s0198-8859(02)00442-1]

Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells

CORTESINI, Raffaello;CINTI, Paola;PRETAGOSTINI, Renzo;
2002

Abstract

Although transplantation tolerance cannot be yet reliably achieved in humans, there is evidence that active immunosuppression contributes to the maintenance of quiescence. However, the mechanism that underlies quiescence and the precise identity of regulatory cells are not completely understood. We have demonstrated that allograft recipients who remain rejection-free display allospecific T-suppressor cells (Ts). Ts express the CD8(+) CD28(-) phenotype, recognize major histocompatibility complex (MHC) class I antigens, and suppress the upregulation of costimulatory molecules induced by CD40 ligation of donor antigen presenting cells. The presence of Ts is inversely correlated with T cell alloreactivity to donor MHC peptides, alloantibody production, and rejection. Monitoring of Ts has been successfully used in our studies for tailoring immunosuppression in kidney and liver allograft recipients. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.
2002
immunosuppression; liver transplantation; renal transplantation; t suppressor cells
01 Pubblicazione su rivista::01a Articolo in rivista
Tailoring of immunosuppression in renal and liver allograft recipients displaying donor specific T-suppressor cells / Cortesini, Raffaello; Elvira Renna, Molajoni; Cinti, Paola; Pretagostini, Renzo; Eric, Ho; Paola, Rossi; Nsf, Cortesini. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 63:11(2002), pp. 1010-1018. [10.1016/s0198-8859(02)00442-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/115971
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