Mol Aspects Med. 2008 Feb-Apr;29(1-2):50-7. Epub 2007 Oct 24. New insights on the molecular and cell biology of human cholangiopathies. Alvaro D, Mancino MG. SourceDivision of Gastroenterology, Department of Clinical Medicine, Rome, Italy. Abstract Cholangiopathies are diseases of high social impact representing the main indication for liver transplantation in the infanthood and the third in adulthood. Despite the heterogeneous etiology and pathogenesis, cholangiopathies share many different common morphological features and, chronically progress toward a ductupenic condition clinically evidenced by the classical features of a cholestatic syndrome. The primary target of damage in the course of cholangiopathies are cholangiocytes, the epithelia cells lining the biliary tree. A bulk of researches performed in the last decade, highlighted the extraordinary biological properties of cholangiocytes involved in a number of important processes such as bile formation, proliferation, injury repair, fibrosis, angiogenesis and regulation of blood flow. Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases. PMID: 18230407 [PubMed - indexed for MEDLINE]
New insights on the molecular and cell biology of human cholangiopathies / Alvaro, Domenico; Mancino, Mg. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - 29:(2008), pp. 50-57. [10.1016/j.mam.2007.09.007]
New insights on the molecular and cell biology of human cholangiopathies.
ALVARO, Domenico;
2008
Abstract
Mol Aspects Med. 2008 Feb-Apr;29(1-2):50-7. Epub 2007 Oct 24. New insights on the molecular and cell biology of human cholangiopathies. Alvaro D, Mancino MG. SourceDivision of Gastroenterology, Department of Clinical Medicine, Rome, Italy. Abstract Cholangiopathies are diseases of high social impact representing the main indication for liver transplantation in the infanthood and the third in adulthood. Despite the heterogeneous etiology and pathogenesis, cholangiopathies share many different common morphological features and, chronically progress toward a ductupenic condition clinically evidenced by the classical features of a cholestatic syndrome. The primary target of damage in the course of cholangiopathies are cholangiocytes, the epithelia cells lining the biliary tree. A bulk of researches performed in the last decade, highlighted the extraordinary biological properties of cholangiocytes involved in a number of important processes such as bile formation, proliferation, injury repair, fibrosis, angiogenesis and regulation of blood flow. Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases. PMID: 18230407 [PubMed - indexed for MEDLINE]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
