Inflammation plays a role in the development and progression of type 2 diabetes macroangiopathy. Interleukin 33 (IL-33) drives production of Th2-associated cytokines. The soluble form of suppression of tumorigenicity 2 (sST2) acting as a decoy receptor blocks IL-33 and tones down Th2 inflammatory response. We investigated the role of sST2 as a predictor of CV and all-cause mortality in a cohort of patients affected by established atherosclerotic disease.
Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects / Cardellini, Marina; Rizza, Stefano; Casagrande, Viviana; Cardolini, Iris; Ballanti, Marta; Davato, Francesca; Porzio, Ottavia; Paola Canale, Maria; Maria Legramante, Jacopo; Mavilio, Maria; Menghini, Rossella; Martelli, Eugenio; Farcomeni, Alessio; Federici, Massimo. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - STAMPA. - (2018). [10.1007/s00592-018-1230-z]
Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects
Alessio Farcomeni;
2018
Abstract
Inflammation plays a role in the development and progression of type 2 diabetes macroangiopathy. Interleukin 33 (IL-33) drives production of Th2-associated cytokines. The soluble form of suppression of tumorigenicity 2 (sST2) acting as a decoy receptor blocks IL-33 and tones down Th2 inflammatory response. We investigated the role of sST2 as a predictor of CV and all-cause mortality in a cohort of patients affected by established atherosclerotic disease.| File | Dimensione | Formato | |
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Cardellini_Soluble ST2_2018.pdf
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