In this paper we report the effect in HT-29 cells of mixed infections with poliovirus type 1 and Shigella flexneri serotype 5 strain M90T and derivative strains differing in adhesive as well as invasive properties. HT-29 epithelial intestinal cells derived from a human colon adenocarcinoma are a good model for coinfection studies because they are susceptible both to poliovirus replication and to S. flexneri invasion. The results show that 48 h after infection by poliovirus the invasiveness of wild-type S. flexneri M90T and of its adherent and invasive derivative M90T (pIL22) is increased. However, the alterations produced in HT-29 cells at the later stage of poliovirus infection are not sufficient to promote the internalization of simply non invasive, or non invasive but adherent, isogenic derivative bacterial strains.

INVASIVENESS OF SHIGELLA-FLEXNERI IN POLIOVIRUS INFECTED HT-29 CELLS / Seganti, Lucilla; Conte, Maria Pia; Longhi, Catia; M., Marchetti; M., Nicoletti; N., Orsi. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 17:(1994), pp. 29-36.

INVASIVENESS OF SHIGELLA-FLEXNERI IN POLIOVIRUS INFECTED HT-29 CELLS

SEGANTI, Lucilla;CONTE, Maria Pia;LONGHI, Catia;
1994

Abstract

In this paper we report the effect in HT-29 cells of mixed infections with poliovirus type 1 and Shigella flexneri serotype 5 strain M90T and derivative strains differing in adhesive as well as invasive properties. HT-29 epithelial intestinal cells derived from a human colon adenocarcinoma are a good model for coinfection studies because they are susceptible both to poliovirus replication and to S. flexneri invasion. The results show that 48 h after infection by poliovirus the invasiveness of wild-type S. flexneri M90T and of its adherent and invasive derivative M90T (pIL22) is increased. However, the alterations produced in HT-29 cells at the later stage of poliovirus infection are not sufficient to promote the internalization of simply non invasive, or non invasive but adherent, isogenic derivative bacterial strains.
1994
01 Pubblicazione su rivista::01a Articolo in rivista
INVASIVENESS OF SHIGELLA-FLEXNERI IN POLIOVIRUS INFECTED HT-29 CELLS / Seganti, Lucilla; Conte, Maria Pia; Longhi, Catia; M., Marchetti; M., Nicoletti; N., Orsi. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 17:(1994), pp. 29-36.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/115600
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