Levels and distribution of heart monoamine oxidases (MAOs) were studied in male Sprague-Dawley rats of 3 (young) and 24 (old) months of age using biochemical and histochemical techniques. Biochemical assay of MAOs in atria and in ventricles showed a significant increase in MAOs levels in old in comparison with young animals. MAOs histochemical staining revealed an homogeneous distribution of the enzyme within both right and left atria and/or ventricles in 3-months-old rats. In 24-months-old rats an increase of MAOs reaction in comparison with younger animals was found. This increase is more consistent in the endocardial portion of the right atrium and in the endocardial portion of the left atrium. In 3-months-old rats MAOs reaction was slightly lower in the epicardial than in the endocardial portions of both atria and/or ventricles. In 24-months-old rats MAOs reaction showed a significant increase if compared with young rats. The significance of these data is discussed in relation to the role of MAOs in rat heart.
Age related changes of the monoamine oxidase in rat heart / Cavallotti, Carlo; Mancone, M.; Artico, M.; Cavallotti, Daniela. - In: BIOMEDICAL RESEARCH. - ISSN 0388-6107. - 23:(2002), pp. 109-113.
Age related changes of the monoamine oxidase in rat heart
CAVALLOTTI, Carlo;MANCONE M.;ARTICO M.;
2002
Abstract
Levels and distribution of heart monoamine oxidases (MAOs) were studied in male Sprague-Dawley rats of 3 (young) and 24 (old) months of age using biochemical and histochemical techniques. Biochemical assay of MAOs in atria and in ventricles showed a significant increase in MAOs levels in old in comparison with young animals. MAOs histochemical staining revealed an homogeneous distribution of the enzyme within both right and left atria and/or ventricles in 3-months-old rats. In 24-months-old rats an increase of MAOs reaction in comparison with younger animals was found. This increase is more consistent in the endocardial portion of the right atrium and in the endocardial portion of the left atrium. In 3-months-old rats MAOs reaction was slightly lower in the epicardial than in the endocardial portions of both atria and/or ventricles. In 24-months-old rats MAOs reaction showed a significant increase if compared with young rats. The significance of these data is discussed in relation to the role of MAOs in rat heart.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
