Inflammatory demyelinating diseases comprise a spectrum of disorders affecting the myelin of the central and peripheral nervous system. These diseases can usually be differentiated on the basis of clinical, radiological, laboratory and pathological findings. Recent studies have contributed to current awareness that inflammatory demyelinating diseases are not restricted to the adult age group, but are more common in pediatric age than previously believed. Some of pediatric inflammatory demyelinating diseases carry an unfavorable long-term prognosis but appropriate treatments can improve the outcome. The possibility of physical and cognitive disability resulting from these diseases, highlights the urgent need for therapeutic strategies for neurorehabilitation, neuroregeneration, and neurorepair. This review discusses characteristics of primary demyelinating diseases more frequently observed in childhood, focusing on epidemiology, clinical aspects and treatments.

Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood. An Update / Properzi, Enrico; Parisi, Pasquale; Papetti, Laura; Nicita, Francesco; Ursitti, Fabiana; DEL BALZO, Francesca; Verrotti, Alberto; Ruggieri, Martino; Iannetti, Paola. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1570-159X. - STAMPA. - 8:2(2010), pp. 135-148. [10.2174/157015910791233141]

Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood. An Update

Enrico Properzi;Pasquale Parisi
Secondo
Writing – Original Draft Preparation
;
Laura Papetti;Francesco Nicita;Fabiana Ursitti;Francesca Del Balzo;Paola Iannetti
2010

Abstract

Inflammatory demyelinating diseases comprise a spectrum of disorders affecting the myelin of the central and peripheral nervous system. These diseases can usually be differentiated on the basis of clinical, radiological, laboratory and pathological findings. Recent studies have contributed to current awareness that inflammatory demyelinating diseases are not restricted to the adult age group, but are more common in pediatric age than previously believed. Some of pediatric inflammatory demyelinating diseases carry an unfavorable long-term prognosis but appropriate treatments can improve the outcome. The possibility of physical and cognitive disability resulting from these diseases, highlights the urgent need for therapeutic strategies for neurorehabilitation, neuroregeneration, and neurorepair. This review discusses characteristics of primary demyelinating diseases more frequently observed in childhood, focusing on epidemiology, clinical aspects and treatments.
2010
adem; demyelinating disease; disease-modifying therapies; immune-mediate polyradiculoneuropathies; immunomodulatory therapy; pediatric multiple sclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood. An Update / Properzi, Enrico; Parisi, Pasquale; Papetti, Laura; Nicita, Francesco; Ursitti, Fabiana; DEL BALZO, Francesca; Verrotti, Alberto; Ruggieri, Martino; Iannetti, Paola. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1570-159X. - STAMPA. - 8:2(2010), pp. 135-148. [10.2174/157015910791233141]
File allegati a questo prodotto
File Dimensione Formato  
Spalice_Clinical-and-Pharmacological_2010.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 322.22 kB
Formato Adobe PDF
322.22 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/115213
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 7
social impact