We performed a dual-task experiment to explore the effect of nabiximols on postural control in 22 patients with multiple sclerosis. They were assessed with static posturography and Stroop test in single- and dual-task conditions at treatment start and after 1, 3 and 12 months. At follow-up, we found more impaired postural control in single-task (F = 3.07, p = 0.044) and dual-task (F = 4.90, p = 0.005) conditions in patients who continued treatment (continuers, n = 11) compared with those who discontinued (quitters, n = 11). Continuers were more impaired at Stroop test only in dual-task condition (F = 3.17, p = 0.038). Our findings suggest that nabiximols had a detrimental effect on postural control, especially in multi-tasking conditions.

Balance worsening associated with nabiximols in multiple sclerosis / Castelli, Letizia; Prosperini, Luca; Pozzilli, Carlo. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 5:1(2019). [10.1177/1352458518765649]

Balance worsening associated with nabiximols in multiple sclerosis

Castelli, Letizia;Prosperini, Luca;Pozzilli, Carlo
2019

Abstract

We performed a dual-task experiment to explore the effect of nabiximols on postural control in 22 patients with multiple sclerosis. They were assessed with static posturography and Stroop test in single- and dual-task conditions at treatment start and after 1, 3 and 12 months. At follow-up, we found more impaired postural control in single-task (F = 3.07, p = 0.044) and dual-task (F = 4.90, p = 0.005) conditions in patients who continued treatment (continuers, n = 11) compared with those who discontinued (quitters, n = 11). Continuers were more impaired at Stroop test only in dual-task condition (F = 3.17, p = 0.038). Our findings suggest that nabiximols had a detrimental effect on postural control, especially in multi-tasking conditions.
2019
balance; Multiple sclerosis; nabiximols; outcome measurement; spasticity; Neurology; Neurology (clinical)
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Balance worsening associated with nabiximols in multiple sclerosis / Castelli, Letizia; Prosperini, Luca; Pozzilli, Carlo. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 5:1(2019). [10.1177/1352458518765649]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1150441
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