OBJECTIVES: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. METHODS: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. RESULTS: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. CONCLUSIONS: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes / Gaetani, L; Prosperini, L; Mancini, A; Eusebi, P; Cerri, Mc; Pozzilli, C; Calabresi, P; Sarchielli, P; Di Filippo, M. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - 265:11(2018), pp. 2684-2687. [10.1007/s00415-018-9048-8]

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Prosperini L;Eusebi P;Pozzilli C;
2018

Abstract

OBJECTIVES: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. METHODS: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. RESULTS: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. CONCLUSIONS: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.
2018
diagnosis criteria, multiple sclerosis, clinically isolated syndromes
01 Pubblicazione su rivista::01a Articolo in rivista
2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes / Gaetani, L; Prosperini, L; Mancini, A; Eusebi, P; Cerri, Mc; Pozzilli, C; Calabresi, P; Sarchielli, P; Di Filippo, M. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - 265:11(2018), pp. 2684-2687. [10.1007/s00415-018-9048-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1150435
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