Background: Recently, significant attention has been paid to the possible activation of an autoimmune response in the presence of obesity. The aim of this study was to evaluate and compare the frequencies of autoantibodies typical of autoimmune diabetes in obese patients with normal glucose tolerance (NGT), obese patients with type 2 diabetes (T2D) and controls. We also evaluated the presence of immunoreactivity to Hashimoto's thyroiditis and autoimmune gastritis. Materials and methods: Consecutive sera from obese patients, 444 with NGT, 322 with T2D, and 212 controls were analysed by radioimmunoassay or enzyme-linked immunosorbent assay for glutamic acid decarboxylase, protein tyrosine phosphatase islet antigen-2 (IA-2)ICand IA-2(256-760), islet beta-cell zinc cation transporter (ZnT8), thyroid peroxidase, and anti-parietal cell autoantibodies. Results: Altogether the presence of organ-specific autoantibodies was significantly more frequent in obese patients with NGT (128/444, 28.5%) and obese with T2D (79/322, 24.5%) than in controls (36/212, 17%; P = 0.002). Thyroid peroxidase immunoreactivity was prevalent in all groups of subjects investigated. The frequencies of diabetes-specific autoantibodies were slightly higher in obese patients with NGT (20/444, 4.5%) than in obese with T2D (12/322, 3.7%) and controls (4/212, 1.9%). The anti IA-2(256-760)was the most frequent islet autoantibody in obese subjects with NGT (14/20, 70%). Conclusions: We observed significant evidence of immunoreactivity specific to diabetes, thyroid, and gastric-parietal cells in obese patients with NGT. The relatively higher frequency of the diabetes-related IA-2(256-760)autoantibodies in obese patients with NGT may suggest that this autoantibody could be associated with obesity the presence of obesity itself.

Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance / Tiberti, Claudio; Zampetti, Simona; Capoccia, Danila; Campagna, Giuseppe; Lucantoni, Federica; Anastasi, Emanuela; Pallotta, Lucia; Panimolle, Francesca; Leto, Gaetano; Lenzi, Andrea; Leonetti, Frida; Buzzetti, Raffaella. - In: DIABETES/METABOLISM RESEARCH AND REVIEWS. - ISSN 1520-7552. - (2018), p. e3055. [10.1002/dmrr.3055]

Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance

Claudio Tiberti;Simona Zampetti;Danila Capoccia;Giuseppe Campagna;Federica Lucantoni;Emanuela Anastasi;Lucia Pallotta;Francesca Panimolle;Gaetano Leto;Andrea Lenzi;Frida Leonetti;Raffaella Buzzetti.
2018

Abstract

Background: Recently, significant attention has been paid to the possible activation of an autoimmune response in the presence of obesity. The aim of this study was to evaluate and compare the frequencies of autoantibodies typical of autoimmune diabetes in obese patients with normal glucose tolerance (NGT), obese patients with type 2 diabetes (T2D) and controls. We also evaluated the presence of immunoreactivity to Hashimoto's thyroiditis and autoimmune gastritis. Materials and methods: Consecutive sera from obese patients, 444 with NGT, 322 with T2D, and 212 controls were analysed by radioimmunoassay or enzyme-linked immunosorbent assay for glutamic acid decarboxylase, protein tyrosine phosphatase islet antigen-2 (IA-2)ICand IA-2(256-760), islet beta-cell zinc cation transporter (ZnT8), thyroid peroxidase, and anti-parietal cell autoantibodies. Results: Altogether the presence of organ-specific autoantibodies was significantly more frequent in obese patients with NGT (128/444, 28.5%) and obese with T2D (79/322, 24.5%) than in controls (36/212, 17%; P = 0.002). Thyroid peroxidase immunoreactivity was prevalent in all groups of subjects investigated. The frequencies of diabetes-specific autoantibodies were slightly higher in obese patients with NGT (20/444, 4.5%) than in obese with T2D (12/322, 3.7%) and controls (4/212, 1.9%). The anti IA-2(256-760)was the most frequent islet autoantibody in obese subjects with NGT (14/20, 70%). Conclusions: We observed significant evidence of immunoreactivity specific to diabetes, thyroid, and gastric-parietal cells in obese patients with NGT. The relatively higher frequency of the diabetes-related IA-2(256-760)autoantibodies in obese patients with NGT may suggest that this autoantibody could be associated with obesity the presence of obesity itself.
autoantibodies; autoimmunity; normal glucose tolerance; obese; type 2 diabetes; Internal Medicine; Endocrinology, Diabetes and Metabolism; Endocrinology
01 Pubblicazione su rivista::01a Articolo in rivista
Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance / Tiberti, Claudio; Zampetti, Simona; Capoccia, Danila; Campagna, Giuseppe; Lucantoni, Federica; Anastasi, Emanuela; Pallotta, Lucia; Panimolle, Francesca; Leto, Gaetano; Lenzi, Andrea; Leonetti, Frida; Buzzetti, Raffaella. - In: DIABETES/METABOLISM RESEARCH AND REVIEWS. - ISSN 1520-7552. - (2018), p. e3055. [10.1002/dmrr.3055]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1148850
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