The introduction of specific drugs for the treatment of pulmonary arterial hypertension over the last 20 years has led to an improvement of clinical and hemodynamic conditions and prognosis of affected patients. The use of combination therapy has made it possible to act simultaneously on several biological pathways involved in the etiopathogenesis of the disease. However, although the diagnosis and management have radically changed in recent years, the disease remains progressive and often fatal. The purpose of this paper is to review and discuss the results of the main clinical trials and the future perspectives of combination strategies for the treatment of pulmonary arterial hypertension.
La terapia di combinazione orale nel trattamento dei pazienti con ipertensione arteriosa polmonare. quali evidenze dagli studi a lungo termine [Oral combination therapy for the treatment of patients with pulmonary arterial hypertension. what evidence from long-term studies] / Pezzuto, Beatrice; Badagliacca, Roberto; Poscia, Roberto; Torre, Roberto; Ghio, Stefano; Scelsi, Laura; Greco, Alessandra; D'Alto, Michele; Argiento, Paola; Vitulo, Patrizio; Fedele, Francesco; Vizza, Carmine Dario. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - ELETTRONICO. - 18:12(2017), pp. 854-861. [10.1714/2815.28469]
La terapia di combinazione orale nel trattamento dei pazienti con ipertensione arteriosa polmonare. quali evidenze dagli studi a lungo termine [Oral combination therapy for the treatment of patients with pulmonary arterial hypertension. what evidence from long-term studies]
Pezzuto, Beatrice;Badagliacca, Roberto;Poscia, Roberto;Torre, Roberto;Greco, Alessandra;Fedele, Francesco;Vizza, Carmine Dario
2017
Abstract
The introduction of specific drugs for the treatment of pulmonary arterial hypertension over the last 20 years has led to an improvement of clinical and hemodynamic conditions and prognosis of affected patients. The use of combination therapy has made it possible to act simultaneously on several biological pathways involved in the etiopathogenesis of the disease. However, although the diagnosis and management have radically changed in recent years, the disease remains progressive and often fatal. The purpose of this paper is to review and discuss the results of the main clinical trials and the future perspectives of combination strategies for the treatment of pulmonary arterial hypertension.File | Dimensione | Formato | |
---|---|---|---|
Pezzuto_Terapia-di-Combinazione_2017.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
185.56 kB
Formato
Adobe PDF
|
185.56 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.