Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis / Guaschino, Clara; Esposito, Federica; Liberatore, Giuseppe; Colombo, Bruno; Annovazzi, Pietro; D'Amico, Emanuele; Cavalla, Paola; Capello, Elisabetta; Capra, Ruggero; Galimberti, Daniela; Tedeschi, Gioacchino; Grimaldi, Luigi; Progresso, Group; Progemus, Group; Salvetti, Marco; Leone, Maurizio; D'Alfonso, Sandra; Martinelli, Vittorio; Comi, Giancarlo; Martinelli-Boneschi, Filippo. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 35:5(2014), pp. 789-791. [10.1007/s10072-014-1650-7]

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

D'Amico, Emanuele;Grimaldi, Luigi;Salvetti,Marco
Membro del Collaboration Group
;
Leone, Maurizio;
2014

Abstract

Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.
2014
multiple sclerosis; progressive; recurrence risk; relapsing-remitting; adult; aged; aged, 80 and over; cluster analysis; disease progression; humans; italy; male; middle aged; multiple sclerosis; prevalence; young adult; family; genetic predisposition to disease; phenotype; 2708; neurology (clinical); psychiatry and mental health
01 Pubblicazione su rivista::01a Articolo in rivista
Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis / Guaschino, Clara; Esposito, Federica; Liberatore, Giuseppe; Colombo, Bruno; Annovazzi, Pietro; D'Amico, Emanuele; Cavalla, Paola; Capello, Elisabetta; Capra, Ruggero; Galimberti, Daniela; Tedeschi, Gioacchino; Grimaldi, Luigi; Progresso, Group; Progemus, Group; Salvetti, Marco; Leone, Maurizio; D'Alfonso, Sandra; Martinelli, Vittorio; Comi, Giancarlo; Martinelli-Boneschi, Filippo. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 35:5(2014), pp. 789-791. [10.1007/s10072-014-1650-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1146625
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