Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.
Molecular insights into muscle homeostasis, atrophy and wasting / Scicchitano, Bianca Maria; Dobrowolny, Gabriella; Sica, Gigliola; Musarò, Antonio. - In: CURRENT GENOMICS. - ISSN 1389-2029. - ELETTRONICO. - 19:5(2018), pp. 356-369. [10.2174/1389202919666180101153911]
Molecular insights into muscle homeostasis, atrophy and wasting
Dobrowolny, Gabriella;Musarò, Antonio
2018
Abstract
Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.| File | Dimensione | Formato | |
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