Background and aims: Aim of this study was to identify subgroups of adults with Type 1 Diabetes Mellitus (T1DM) treated with Continuous Subcutaneous Insulin Infusion (CSII) at higher risk of poor quality of life (QoL). A sample of consecutive patients completed the Diabetes Specific Quality of Life Scale (DSQOLS), investigating the daily burden and restrictions related to diabetes. Lower DSQOLS scores indicate worse QoL perception. Methods and results: The main results were obtained by using a regression-tree technique (RECursive Partitioning and AMalgamation - RECPAM) and multivariate logistic regression. Overall, 472 patients aged between 18 and 55 years were recruited by 43 Italian centers. RECPAM analysis led to the identification of 5 classes characterized by a marked difference in QoL. Male patients not reporting episodes of ketoacidosis and using CSII for >2 years had the lowest likelihood of scoring in the lower tertile of the DSQOLS summary score, and thus represented the reference category. Patients who reported ≥1 ketoacidosis episodes (OR = 5.4; 95% CI 2.4-12.1) and female patients with a duration of diabetes of <10 years (OR = 5.9; 95% CI 2.6-13.5) had the highest likelihood of reporting poor QoL, while females with longer diabetes duration (OR = 2.4; 95% CI 1.3-4.7) and males treated with CSII for ≤2 years (OR = 2.2; 95% CI 1.1-4.6) showed a two-fold risk of poor QoL. Patient age, diabetic complications and civil status were globally predictive variables associated with poor QoL. Conclusion: We identified subgroups of T1DM individuals treated with CSII showing a major impairment in QoL. Specific strategies are needed to help the patient cope with this therapeutic modality, especially during the initial phase of treatment. © 2009 Elsevier B.V. All rights reserved.

Correlates of quality of life in adults with type 1 diabetes treated with continuous subcutaneous insulin injection / M., Franciosi; A., Maione; B., Pomili; R., Amoretti; E., Busetto; F., Capani; D., Bruttomesso; P., Di Bartolo; A., Girelli; Leonetti, Frida; L., Morviducci; P., Ponzi; E., Vitacolonna; A., Nicolucci. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 20:1(2010), pp. 7-14. [10.1016/j.numecd.2009.02.012]

Correlates of quality of life in adults with type 1 diabetes treated with continuous subcutaneous insulin injection

LEONETTI, Frida;
2010

Abstract

Background and aims: Aim of this study was to identify subgroups of adults with Type 1 Diabetes Mellitus (T1DM) treated with Continuous Subcutaneous Insulin Infusion (CSII) at higher risk of poor quality of life (QoL). A sample of consecutive patients completed the Diabetes Specific Quality of Life Scale (DSQOLS), investigating the daily burden and restrictions related to diabetes. Lower DSQOLS scores indicate worse QoL perception. Methods and results: The main results were obtained by using a regression-tree technique (RECursive Partitioning and AMalgamation - RECPAM) and multivariate logistic regression. Overall, 472 patients aged between 18 and 55 years were recruited by 43 Italian centers. RECPAM analysis led to the identification of 5 classes characterized by a marked difference in QoL. Male patients not reporting episodes of ketoacidosis and using CSII for >2 years had the lowest likelihood of scoring in the lower tertile of the DSQOLS summary score, and thus represented the reference category. Patients who reported ≥1 ketoacidosis episodes (OR = 5.4; 95% CI 2.4-12.1) and female patients with a duration of diabetes of <10 years (OR = 5.9; 95% CI 2.6-13.5) had the highest likelihood of reporting poor QoL, while females with longer diabetes duration (OR = 2.4; 95% CI 1.3-4.7) and males treated with CSII for ≤2 years (OR = 2.2; 95% CI 1.1-4.6) showed a two-fold risk of poor QoL. Patient age, diabetic complications and civil status were globally predictive variables associated with poor QoL. Conclusion: We identified subgroups of T1DM individuals treated with CSII showing a major impairment in QoL. Specific strategies are needed to help the patient cope with this therapeutic modality, especially during the initial phase of treatment. © 2009 Elsevier B.V. All rights reserved.
2010
csii; recpam analysis; type 1 diabetes; quality of life
01 Pubblicazione su rivista::01a Articolo in rivista
Correlates of quality of life in adults with type 1 diabetes treated with continuous subcutaneous insulin injection / M., Franciosi; A., Maione; B., Pomili; R., Amoretti; E., Busetto; F., Capani; D., Bruttomesso; P., Di Bartolo; A., Girelli; Leonetti, Frida; L., Morviducci; P., Ponzi; E., Vitacolonna; A., Nicolucci. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 20:1(2010), pp. 7-14. [10.1016/j.numecd.2009.02.012]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/114356
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