Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apoptosis resistance in RA. In this review, we summarize the current knowledge on the role of autophagy in RA and discuss the possibility of a clinical application of autophagy modulation in this disease.

Autophagy and rheumatoid arthritis: Current knowledges and future perspectives / Vomero, Marta; Barbati, Cristiana; Colasanti, Tania; Perricone, Carlo; Novelli, Lucia; Ceccarelli, Fulvia; Spinelli, Francesca Romana; Franco, Manuela Di; Conti, Fabrizio; Valesini, Guido; Alessandri, Cristiano. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 9:JUL(2018), p. 1577. [10.3389/fimmu.2018.01577]

Autophagy and rheumatoid arthritis: Current knowledges and future perspectives

Vomero, Marta;Barbati, Cristiana;Colasanti, Tania;Perricone, Carlo;Novelli, Lucia;Ceccarelli, Fulvia;Spinelli, Francesca Romana;Franco, Manuela Di;Conti, Fabrizio;Valesini, Guido;Alessandri, Cristiano
2018

Abstract

Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apoptosis resistance in RA. In this review, we summarize the current knowledge on the role of autophagy in RA and discuss the possibility of a clinical application of autophagy modulation in this disease.
2018
Apoptosis; Autoimmunity; Autophagy; Citrullination; Rheumatoid arthritis; Immunology and Allergy; Immunology
01 Pubblicazione su rivista::01a Articolo in rivista
Autophagy and rheumatoid arthritis: Current knowledges and future perspectives / Vomero, Marta; Barbati, Cristiana; Colasanti, Tania; Perricone, Carlo; Novelli, Lucia; Ceccarelli, Fulvia; Spinelli, Francesca Romana; Franco, Manuela Di; Conti, Fabrizio; Valesini, Guido; Alessandri, Cristiano. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 9:JUL(2018), p. 1577. [10.3389/fimmu.2018.01577]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1142730
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