In the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5, has been mapped to chromosome 1. Because mouse chromosome 1 shares a homologous 33-cM region between the genes col3a1 and col6a3 with human chromosome 2q31–q35, several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evidence for at least three type 1 diabetes loci (IDDM7, IDDM12, and IDDM13) within a 23-cM region of chromosome 2q31–q35 (2–5). We have now evaluated linkage on chromosome 2, by multipoint analysis using Mapmaker/Sibs, of 34 microsatellite markers and an interleukin-1 (IL-1) β TaqI polymorphism in 352 U.K. families.
Genetic analysis of chromosome 2 in type 1 dibetes: analyis of putative loci IDDM7,IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and intreleukin-1 gene cluster.IMDIAB Group / Esposito, L; Hill, Nj; Prichard, Le; Cucca, F; Muxworthy, C; Merriman, Me; Wilson, A; Julier, C; Delepine, M; Tuomilehto, J; TUOMILEHTO WOLF, E; Buzzetti, Raffaella; Joner, G; Thorsby, E; Undlien, De; Pociot, F; Nerup, J; Ronningen, Ks; Todd, Ja. - In: DIABETES. - ISSN 0012-1797. - 47(11):(1998), pp. 1797-1799.
Genetic analysis of chromosome 2 in type 1 dibetes: analyis of putative loci IDDM7,IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and intreleukin-1 gene cluster.IMDIAB Group
BUZZETTI, Raffaella;
1998
Abstract
In the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5, has been mapped to chromosome 1. Because mouse chromosome 1 shares a homologous 33-cM region between the genes col3a1 and col6a3 with human chromosome 2q31–q35, several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evidence for at least three type 1 diabetes loci (IDDM7, IDDM12, and IDDM13) within a 23-cM region of chromosome 2q31–q35 (2–5). We have now evaluated linkage on chromosome 2, by multipoint analysis using Mapmaker/Sibs, of 34 microsatellite markers and an interleukin-1 (IL-1) β TaqI polymorphism in 352 U.K. families.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
