Dosaggio della Carbohidrate-Deficient Tranferrin (CDT) in addetti alla guida di veicoli stradali

The purpose of this study is to estimate abuse of alcohol in the drivers, they are a risk for chronic alcoholism. It has been detected elevation of the serum Carbohidrate-Deficient Transferrin (CDT), biomarker of high and prolonged consumption of alcohol, analyzed by HLPC (High Pressure Liquid Chromatography), alterations of enzymes of liver damage (ALT, AST, GGT) and erythrocyte mean corpuscular volume (MCV), as indicators traditionally associated with dependencies by alcohol, on 105 drivers observed in the last year, all male and mean age 46 ± 8.82 years. Data analysis revealed conditions of alcohol dependence, measured by increase in CDT (cut-off 2.6%), in three subjects (2.85%). In a event (33.33%) the increase of the CDT it is associated with alterations of ALT, AST and GGT, while there aren't change in the MCV. The evidence emerged confirming the CDT gold standard for the estimation of dependence by alcohol and early indicator than other traditional indicators.