Autism spectrum disorder (ASD) is more commonly diagnosed in males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an environmental risk factor of ASD. Male rats prenatally exposed to VPA show socio-emotional autistic-like dysfunctions that have been related to changes in the activity of the endocannabinoid anandamide. Here, we have investigated if prenatal VPA induced sex-specific autistic endophenotypes involving anandamide signalling.
Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling / Melancia, Francesca; Schiavi, Sara; Servadio, Michela; Cartocci, Veronica; Campolongo, Patrizia; Palmery, Maura; Pallottini, Valentina; Trezza, Viviana. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 175:18(2018), pp. 3699-3712. [10.1111/bph.14435]
Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling
Campolongo, Patrizia;PALMERY, Maura;
2018
Abstract
Autism spectrum disorder (ASD) is more commonly diagnosed in males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an environmental risk factor of ASD. Male rats prenatally exposed to VPA show socio-emotional autistic-like dysfunctions that have been related to changes in the activity of the endocannabinoid anandamide. Here, we have investigated if prenatal VPA induced sex-specific autistic endophenotypes involving anandamide signalling.| File | Dimensione | Formato | |
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