Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements.

Effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans / Guerra, Andrea; Bologna, Matteo; Paparella, Giulia; Suppa, Antonio; Colella, Donato; Di Lazzaro, Vincenzo; Brown, Peter; Berardelli, Alfredo. - In: NEURAL PLASTICITY. - ISSN 2090-5904. - ELETTRONICO. - 2018:(2018). [10.1155/2018/4593095]

Effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans

Guerra, Andrea;Bologna, Matteo
;
Paparella, Giulia;Suppa, Antonio;Colella, Donato;Berardelli, Alfredo
2018

Abstract

Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements.
2018
Transcranial alternating current stimulation (tACS), voluntary movements, M1 excitability
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans / Guerra, Andrea; Bologna, Matteo; Paparella, Giulia; Suppa, Antonio; Colella, Donato; Di Lazzaro, Vincenzo; Brown, Peter; Berardelli, Alfredo. - In: NEURAL PLASTICITY. - ISSN 2090-5904. - ELETTRONICO. - 2018:(2018). [10.1155/2018/4593095]
File allegati a questo prodotto
File Dimensione Formato  
Guerra_Effects of transcranial alternating_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 914.37 kB
Formato Adobe PDF
914.37 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1137719
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 30
social impact