In 36 patients suffering from systemic lupus erythematosus (SLE), lupus anticoagulant (LA), as assessed by aPTT and diluted aPTT, and anticardiolipin antibodies (aCL) were studied. 14 patients, had a clinical history complicated by thrombosis and/or miscarriages. Among patients with thrombosis LA was positive in 42% and in 100% of patients when assessed by aPTT and diluted aPTT respectively; aCL were positive in 85.7% of patients. Among patients without a clinical history of thrombosis, 1 had prolonged aPTT, 3 had prolonged diluted aPTT and 5 had aCL positivity. Diluted aPTT was more sensitive than aPTT and aCL (p less than 0.01) to thrombosis and miscarriages; specificity to thrombosis and miscarriages ranged from 77.3% for aCL and 86.4% for diluted aPTT to 95.5% for aPTT but not significant differences were found. The study suggests that LA, as assessed by a sensitive test like diluted aPTT, is strongly associated to thrombosis and should therefore be considered an important risk factor.

Specificity and sensitivity of diluted aPTT and anticardiolipin antibodies towards thrombosis and miscarriages in patients with systemic lupus erythematosus / Ferro, Domenico; Saliola, Mirella; C., Quintarelli; Carlucci, Margherita; Valesini, Guido; Violi, Francesco. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - STAMPA. - 59:3(1990), pp. 609-617. [10.1016/0049-3848(90)90419-d]

Specificity and sensitivity of diluted aPTT and anticardiolipin antibodies towards thrombosis and miscarriages in patients with systemic lupus erythematosus

FERRO, Domenico;SALIOLA, Mirella;CARLUCCI, Margherita;VALESINI, Guido;VIOLI, Francesco
1990

Abstract

In 36 patients suffering from systemic lupus erythematosus (SLE), lupus anticoagulant (LA), as assessed by aPTT and diluted aPTT, and anticardiolipin antibodies (aCL) were studied. 14 patients, had a clinical history complicated by thrombosis and/or miscarriages. Among patients with thrombosis LA was positive in 42% and in 100% of patients when assessed by aPTT and diluted aPTT respectively; aCL were positive in 85.7% of patients. Among patients without a clinical history of thrombosis, 1 had prolonged aPTT, 3 had prolonged diluted aPTT and 5 had aCL positivity. Diluted aPTT was more sensitive than aPTT and aCL (p less than 0.01) to thrombosis and miscarriages; specificity to thrombosis and miscarriages ranged from 77.3% for aCL and 86.4% for diluted aPTT to 95.5% for aPTT but not significant differences were found. The study suggests that LA, as assessed by a sensitive test like diluted aPTT, is strongly associated to thrombosis and should therefore be considered an important risk factor.
1990
lupus anticoagulant; anticardiolipin antibodies; miscarriages; systemic lupus erythematosis; thrombosis
01 Pubblicazione su rivista::01a Articolo in rivista
Specificity and sensitivity of diluted aPTT and anticardiolipin antibodies towards thrombosis and miscarriages in patients with systemic lupus erythematosus / Ferro, Domenico; Saliola, Mirella; C., Quintarelli; Carlucci, Margherita; Valesini, Guido; Violi, Francesco. - In: THROMBOSIS RESEARCH. - ISSN 0049-3848. - STAMPA. - 59:3(1990), pp. 609-617. [10.1016/0049-3848(90)90419-d]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/113175
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