In literature, the importance of X-linked gene dosage as a contributing factor for autoimmune diseases is generally assumed. However, little information is available on the frequency of humoral endocrine organ-specific autoimmunity in X-chromosome aneuploidies. In our preliminary study, we investigated the endocrine organ-specific humoral autoimmunity relative to four different organ-specific autoimmune diseases in a group of adult 47,XXY KS patients and in adults 46,XY control males (type 1 diabetes, T1DM; Addison's disease, AD; Hashimoto thyroiditis, HT; autoimmune chronic atrophic gastritis, AG). The aim of the present study is to evaluate the frequency of autoantibodies (Abs) specific for T1DM, AD, HT, and AG in rarer higher grade X-chromosome aneuploidies (HGA) and in 47,XXY children.

Evidence of increased humoral endocrine organ-specific autoimmunity in severe and classic X-chromosome aneuploidies in comparison with 46,XY control subjects / Panimolle, Francesca; Tiberti, Claudio; Granato, Simona; Anzuini, Antonella; Pozza, Carlotta; Lenzi, Andrea; Radicioni, Antonio. - In: AUTOIMMUNITY. - ISSN 0891-6934. - 51:4(2018), pp. 175-182. [10.1080/08916934.2018.1477134]

Evidence of increased humoral endocrine organ-specific autoimmunity in severe and classic X-chromosome aneuploidies in comparison with 46,XY control subjects

Panimolle, Francesca;Tiberti, Claudio;Granato, Simona;Anzuini, Antonella;Pozza, Carlotta;Lenzi, Andrea;Radicioni, Antonio
2018

Abstract

In literature, the importance of X-linked gene dosage as a contributing factor for autoimmune diseases is generally assumed. However, little information is available on the frequency of humoral endocrine organ-specific autoimmunity in X-chromosome aneuploidies. In our preliminary study, we investigated the endocrine organ-specific humoral autoimmunity relative to four different organ-specific autoimmune diseases in a group of adult 47,XXY KS patients and in adults 46,XY control males (type 1 diabetes, T1DM; Addison's disease, AD; Hashimoto thyroiditis, HT; autoimmune chronic atrophic gastritis, AG). The aim of the present study is to evaluate the frequency of autoantibodies (Abs) specific for T1DM, AD, HT, and AG in rarer higher grade X-chromosome aneuploidies (HGA) and in 47,XXY children.
2018
Klinefelter’s syndrome; X-chromosome; humoral autoimmunity; hypogonadism; type 1 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Evidence of increased humoral endocrine organ-specific autoimmunity in severe and classic X-chromosome aneuploidies in comparison with 46,XY control subjects / Panimolle, Francesca; Tiberti, Claudio; Granato, Simona; Anzuini, Antonella; Pozza, Carlotta; Lenzi, Andrea; Radicioni, Antonio. - In: AUTOIMMUNITY. - ISSN 0891-6934. - 51:4(2018), pp. 175-182. [10.1080/08916934.2018.1477134]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1130636
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