Aripiprazole-triggered Alice in Wonderland syndrome episodes studied with 99mTc-HMPAO brain SPECT

Migraine and major depression treated with aripiprazole, reported a change in her aura with the appearance of mosaic vision and left-side macrosomatognosia (Fig. 1). These body misperceptions, known as Alice in Wonderland Syndrome (AIWS), were correlated to aripiprazole intake after autonomous discontinuation and followed by migraine. Interestingly, among the causes of AIWS, there are both migraine and some drugs [1–2], but this is the first case of AIWS attributable to an antipsychotic.