Botulinum toxin type A (BoNT-A) injections are recommended for the management of upper limb spasticity (ULS) and cervical dystonia (CD). The main aim of this cost minimization analysis (CMA) was to compare the annual cost per patient for three BoNT-As (Botox®, Dysport® and Xeomin®) in the treatment of ULS or CD in Italy. A budget impact analysis (BIA) was also conducted. Methods The CMA was conducted from the perspective of the Italian National Health Service. Only direct medical costs (BoNT-A and standard therapy) were considered. By using a Delphi panel of twelve Italian Experts in the treatment of ULS and CD, data was collected about BoNT-As (dose, number of administrations and acquisition price) and standard therapy (concomitant medications, visits, Day-Hospital, hospitalizations, etc.). Costs were assessed in Euros 2014. The BIA was conducted to evaluate the pharmaceutical expenditure for the three BoNT-As on a five-year time horizon. A sensitivity analysis was conducted. Results The mean annual cost per patient with ULS was €1,840.20 with Dysport®, €2,067.12 with Botox® and €2,171.05 with Xeomin®. The mean annual cost per patient with CD was €1,353.79 with Dysport®, €1,433.12 with Botox® and €1,503.60 with Xeomin®. In the time horizon considered, the substitution process of Botox® and Xeomin® by Dysport® would result in a total saving of €620,000 when treating ULS and a total saving of €481,000 in the case of CD. Sensitivity and probabilistic analyses showed the robustness of results. Conclusions From the Italian National Health Service's perspective, Dysport® appears to be the cost-saving therapeutic option compared with Botox® and Xeomin® in the treatment of ULS or CD.

Cost minimization analysis of BoNT-As in the treatment of upper limb spasticity and cervical dystonia / Bartolomei, Luigi; Bentivoglio, Anna Rita; Bizzarini, Massimo; Caglioni, Patrizia Maria; Cerbarano, Luana; Frontoni, Marco; Lus, Giacomo; Majorana, Giovanni; Nassetti, Stefania Alessandra; Osio, Maurizio; Ravasio, Roberto; Ravenni, Roberta; Santoro, Antonio; Smania, Nicola; Torlizzi, Flavia; Valvo, Sebastiana Claudia. - ELETTRONICO. - 3:1(2016), pp. 23-31. [10.5301/GRHTA.5000207]

Cost minimization analysis of BoNT-As in the treatment of upper limb spasticity and cervical dystonia

Frontoni, Marco;
2016

Abstract

Botulinum toxin type A (BoNT-A) injections are recommended for the management of upper limb spasticity (ULS) and cervical dystonia (CD). The main aim of this cost minimization analysis (CMA) was to compare the annual cost per patient for three BoNT-As (Botox®, Dysport® and Xeomin®) in the treatment of ULS or CD in Italy. A budget impact analysis (BIA) was also conducted. Methods The CMA was conducted from the perspective of the Italian National Health Service. Only direct medical costs (BoNT-A and standard therapy) were considered. By using a Delphi panel of twelve Italian Experts in the treatment of ULS and CD, data was collected about BoNT-As (dose, number of administrations and acquisition price) and standard therapy (concomitant medications, visits, Day-Hospital, hospitalizations, etc.). Costs were assessed in Euros 2014. The BIA was conducted to evaluate the pharmaceutical expenditure for the three BoNT-As on a five-year time horizon. A sensitivity analysis was conducted. Results The mean annual cost per patient with ULS was €1,840.20 with Dysport®, €2,067.12 with Botox® and €2,171.05 with Xeomin®. The mean annual cost per patient with CD was €1,353.79 with Dysport®, €1,433.12 with Botox® and €1,503.60 with Xeomin®. In the time horizon considered, the substitution process of Botox® and Xeomin® by Dysport® would result in a total saving of €620,000 when treating ULS and a total saving of €481,000 in the case of CD. Sensitivity and probabilistic analyses showed the robustness of results. Conclusions From the Italian National Health Service's perspective, Dysport® appears to be the cost-saving therapeutic option compared with Botox® and Xeomin® in the treatment of ULS or CD.
BoNT-A; cervical dystonia; cost-minimization analysis; upper limb spasticity
01 Pubblicazione su rivista::01a Articolo in rivista
Cost minimization analysis of BoNT-As in the treatment of upper limb spasticity and cervical dystonia / Bartolomei, Luigi; Bentivoglio, Anna Rita; Bizzarini, Massimo; Caglioni, Patrizia Maria; Cerbarano, Luana; Frontoni, Marco; Lus, Giacomo; Majorana, Giovanni; Nassetti, Stefania Alessandra; Osio, Maurizio; Ravasio, Roberto; Ravenni, Roberta; Santoro, Antonio; Smania, Nicola; Torlizzi, Flavia; Valvo, Sebastiana Claudia. - ELETTRONICO. - 3:1(2016), pp. 23-31. [10.5301/GRHTA.5000207]
File allegati a questo prodotto
File Dimensione Formato  
Bartolomei_Cost minimization analysis of BoNT-As_2016.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 572.87 kB
Formato Adobe PDF
572.87 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1127692
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 1
social impact