In-Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.

Computing personalised treatments through In Silico Clinical Trials. A case Study on downregulation in assisted reproduction / Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, Stefano; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, and B.. - ELETTRONICO. - 2271:(2018). (Intervento presentato al convegno 25th International Workshop on Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion, RCRA 2018 tenutosi a Oxford, UK).

Computing personalised treatments through In Silico Clinical Trials. A case Study on downregulation in assisted reproduction.

T. Mancini
;
F. Mari
;
A. Massini
;
I. Melatti
;
I. Salvo
;
SINISI, STEFANO
;
E. Tronci
;
2018

Abstract

In-Silico Clinical Trials (ISCT), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present a case study aiming at quantifying, by means of a multi-arm ISCT supervised by intelligent search, the potential impact of precision medicine approaches on a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction.
2018
25th International Workshop on Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion, RCRA 2018
search; hybrid system; simulators; virtual physiological human; precision medicine
04 Pubblicazione in atti di convegno::04b Atto di convegno in volume
Computing personalised treatments through In Silico Clinical Trials. A case Study on downregulation in assisted reproduction / Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, Stefano; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, and B.. - ELETTRONICO. - 2271:(2018). (Intervento presentato al convegno 25th International Workshop on Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion, RCRA 2018 tenutosi a Oxford, UK).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1123936
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