AIMS: We aim to test and compare the effects of Flavonoids (Fs) and Centella asiatica (Ca), and the traditional treatment to find out which best deals with healing time, bleeding and pain in the treatment of chronic Anal Fissure (AF). Materials of Study: 98 outpatients were divided randomly into treated (either Fs or Ca) and control group. The control group (Group C, n=32) received the traditional treatment along with the other two subgroups which were treated, additionally, with Fs (Group A, n=30) or Ca (Group B, n=36). Patients were observed once weekly over 8 consecutive weeks. RESULTS: The median time to stop bleeding in the group A was 1 week, in the Group B was 3 weeks and in the group C was 4 weeks. There were significant differences between Groups in terms of time to end bleeding (A vs B: p-value= 0.022; A vs C: p-value<0.001; B vs C: p-value=0.070). As for pain score from baseline to the 2nd week were statistically different between Groups A and B on the one hand and Group C on the other hand (A vs C: p-value=0.004; B vs C: p-value 0.035). All patients healed within 8th week. DISCUSSION: Either patients treated with Fs or Ca experienced early pain disappearance. Fs and Ca did not show side effects CONCLUSIONS: The treatment with Fs is the most effective for bleeding. Patients additionally treated with either Fs or Ca experienced an earlier healing and disappearance of pain in comparison with patients underwent to the traditional treatment.

Il presente studio longitudinale randomizzatosi è proposto di valutare comparativamente l'efficacia dell'impiego di Flavonoidi (Fs) e di estratti di Centella asiatica (Ca) studiando il tempo di scomparsa di sanguinamento, dolore, sensazione di peso e tenesmo in pazienti affetti da ragade anale cronica (RA)

Comparison of flavonoids and centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial / Chiaretti, M; Alunni Fegatelli, D; Ceccarelli, G; Carru, Ga; Pappalardo, G; Chiaretti, Ai. - In: ANNALI ITALIANI DI CHIRURGIA. - ISSN 2239-253X. - ELETTRONICO. - 89:3(2018).

Comparison of flavonoids and centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial

Chiaretti M
Conceptualization
;
Alunni Fegatelli D
Validation
;
Ceccarelli G
Writing – Review & Editing
;
Carru GA
Investigation
;
Pappalardo G
Supervision
;
2018

Abstract

AIMS: We aim to test and compare the effects of Flavonoids (Fs) and Centella asiatica (Ca), and the traditional treatment to find out which best deals with healing time, bleeding and pain in the treatment of chronic Anal Fissure (AF). Materials of Study: 98 outpatients were divided randomly into treated (either Fs or Ca) and control group. The control group (Group C, n=32) received the traditional treatment along with the other two subgroups which were treated, additionally, with Fs (Group A, n=30) or Ca (Group B, n=36). Patients were observed once weekly over 8 consecutive weeks. RESULTS: The median time to stop bleeding in the group A was 1 week, in the Group B was 3 weeks and in the group C was 4 weeks. There were significant differences between Groups in terms of time to end bleeding (A vs B: p-value= 0.022; A vs C: p-value<0.001; B vs C: p-value=0.070). As for pain score from baseline to the 2nd week were statistically different between Groups A and B on the one hand and Group C on the other hand (A vs C: p-value=0.004; B vs C: p-value 0.035). All patients healed within 8th week. DISCUSSION: Either patients treated with Fs or Ca experienced early pain disappearance. Fs and Ca did not show side effects CONCLUSIONS: The treatment with Fs is the most effective for bleeding. Patients additionally treated with either Fs or Ca experienced an earlier healing and disappearance of pain in comparison with patients underwent to the traditional treatment.
2018
Il presente studio longitudinale randomizzatosi è proposto di valutare comparativamente l'efficacia dell'impiego di Flavonoidi (Fs) e di estratti di Centella asiatica (Ca) studiando il tempo di scomparsa di sanguinamento, dolore, sensazione di peso e tenesmo in pazienti affetti da ragade anale cronica (RA)
Anal bleeding; anal fissure; defecation pain
01 Pubblicazione su rivista::01a Articolo in rivista
Comparison of flavonoids and centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial / Chiaretti, M; Alunni Fegatelli, D; Ceccarelli, G; Carru, Ga; Pappalardo, G; Chiaretti, Ai. - In: ANNALI ITALIANI DI CHIRURGIA. - ISSN 2239-253X. - ELETTRONICO. - 89:3(2018).
File allegati a questo prodotto
File Dimensione Formato  
Chiaretti_Flavonoids-centella.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 257.44 kB
Formato Adobe PDF
257.44 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1123083
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 2
social impact