Higenamine is a prohibited substance, included in S3 section “β2-agonists” of the World Anti-Doping Agency (WADA) List of Prohibited Substances and Methods [1]. It is anatural alkaloid firstly identified and purified from Aconitum japonicum [2], but present in other plants as a precursor in the biosynthesis of benzylisoquinoline alkaloids [3]. Either because the large use of botanical components in the composition of natural products and because of the wide distribution benzylisoquinoline derivatives in plants, the ingredients should be taken into consideration as possible sources of higenamine to prevent its non voluntary assumption. The purpose of this work was to verify the possible presence of higenamine, not declared on the label, in an herbal cream after an adverse analytical finding reported by our laboratory . The investigation has been carried out following the request, and with the consensus, of the Testing Authority
Higenamine and coclaurine positive doping case associated with herbal massage cream use / Comunità, F; de la Torre, X; Mazzarino, M; Botrè, F. - STAMPA. - (2017), pp. 47-50. (Intervento presentato al convegno XXXV Cologne Workshop on Dope Analysis tenutosi a Colonia, Germania).
Higenamine and coclaurine positive doping case associated with herbal massage cream use
Botrè F
2017
Abstract
Higenamine is a prohibited substance, included in S3 section “β2-agonists” of the World Anti-Doping Agency (WADA) List of Prohibited Substances and Methods [1]. It is anatural alkaloid firstly identified and purified from Aconitum japonicum [2], but present in other plants as a precursor in the biosynthesis of benzylisoquinoline alkaloids [3]. Either because the large use of botanical components in the composition of natural products and because of the wide distribution benzylisoquinoline derivatives in plants, the ingredients should be taken into consideration as possible sources of higenamine to prevent its non voluntary assumption. The purpose of this work was to verify the possible presence of higenamine, not declared on the label, in an herbal cream after an adverse analytical finding reported by our laboratory . The investigation has been carried out following the request, and with the consensus, of the Testing AuthorityI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.