Radioactive iodine is a crucial tool for treatment of differentiated thyroid cancer (DTC). In 5% of cases, DTCs lose I-131 avidity and assume an aggressive behaviour. Treatment options for iodine-refractory DTC are limited. We report the experience of off-label use of the tyrosine kinase inhibitor sorafenib for treatment of advanced iodine-refractory DTC.

Sorafenib in advanced iodine-refractory differentiated thyroid cancer: efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET / Marotta, Vincenzo; Ramundo, Valeria; Camera, Luigi; Del Prete, Michela; Fonti, Rosa; Esposito, Raffaella; Palmieri, Giovannella; Salvatore, Marco; Vitale, Mario; Colao, Annamaria; Faggiano, Antongiulio. - In: CLINICAL ENDOCRINOLOGY. - ISSN 1365-2265. - 78:5(2013), pp. 760-767. [10.1111/cen.12057]

Sorafenib in advanced iodine-refractory differentiated thyroid cancer: efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET

Ramundo, Valeria;Faggiano, Antongiulio
2013

Abstract

Radioactive iodine is a crucial tool for treatment of differentiated thyroid cancer (DTC). In 5% of cases, DTCs lose I-131 avidity and assume an aggressive behaviour. Treatment options for iodine-refractory DTC are limited. We report the experience of off-label use of the tyrosine kinase inhibitor sorafenib for treatment of advanced iodine-refractory DTC.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1120281
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