Salem and colleagues evaluated the proliferative response of splenic T cells to peptides spanning the entire sequence of human β2GPI. They found that mice with induced and spontaneous SLE recognize a common T cell epitope in Domain III of β2GPI. β2GPI-reactive CD4+ T cells from the two models differed primarily in cytokine production, IFN-γ or both IL-17 and IFN-γ, respectively. This study supports the role the role of Domain III of β2GPI in T cell response of mice with SLE. β2GPI consists of 5 domains, that exist either in circular or linear form, depending on its binding to anionic phospholipids. Among these, Domain I represents the main antigenic target for autoantibodies, Domain V is responsible for the interaction with negatively charged phospholipids. Thus, different domains of β2GPI may play a role in the pathogenesis of autoimmune diseases. It may open future progress of potential peptide- or β2GPI domain-based therapeutic strategies.

Different domains of β2-glycoprotein I play a role in autoimmune pathogenesis / Sorice, Maurizio; Misasi, Roberta. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 2042-0226. - STAMPA. - (2018). [10.1038/s41423-018-0060-9]

Different domains of β2-glycoprotein I play a role in autoimmune pathogenesis.

Maurizio Sorice;Roberta Misasi
2018

Abstract

Salem and colleagues evaluated the proliferative response of splenic T cells to peptides spanning the entire sequence of human β2GPI. They found that mice with induced and spontaneous SLE recognize a common T cell epitope in Domain III of β2GPI. β2GPI-reactive CD4+ T cells from the two models differed primarily in cytokine production, IFN-γ or both IL-17 and IFN-γ, respectively. This study supports the role the role of Domain III of β2GPI in T cell response of mice with SLE. β2GPI consists of 5 domains, that exist either in circular or linear form, depending on its binding to anionic phospholipids. Among these, Domain I represents the main antigenic target for autoantibodies, Domain V is responsible for the interaction with negatively charged phospholipids. Thus, different domains of β2GPI may play a role in the pathogenesis of autoimmune diseases. It may open future progress of potential peptide- or β2GPI domain-based therapeutic strategies.
2018
Autoimmunity, beta2GPI, epitopes
01 Pubblicazione su rivista::01a Articolo in rivista
Different domains of β2-glycoprotein I play a role in autoimmune pathogenesis / Sorice, Maurizio; Misasi, Roberta. - In: CELLULAR & MOLECULAR IMMUNOLOGY. - ISSN 2042-0226. - STAMPA. - (2018). [10.1038/s41423-018-0060-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1119501
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