Adrenal insufficiency (AI) requires life-long glucocorticoid replacement. Conventional therapies fail to mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling an organ's circadian function and are influenced by glucocorticoids. However, clock gene expression has never been investigated in AI patients.
Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a dream trial ancillary study / Venneri, Mary Anna; Hasenmajer, Valeria; Fiore, Daniela; Sbardella, Emilia; Pofi, Riccardo; Graziadio, Chiara; Gianfrilli, Daniele; Pivonello, Claudia; Negri, Mariarosaria; Naro, Fabio; Grossman, Ashley B; Lenzi, Andrea; Pivonello, Rosario; Isidori, Andrea M. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 103:8(2018), pp. 2998-3009. [10.1210/jc.2018-00346]
Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a dream trial ancillary study
Venneri, Mary Anna;Hasenmajer, Valeria;Fiore, Daniela;Sbardella, Emilia;Pofi, Riccardo;Graziadio, Chiara;Gianfrilli, Daniele;Naro, Fabio;Lenzi, Andrea;Isidori, Andrea M
2018
Abstract
Adrenal insufficiency (AI) requires life-long glucocorticoid replacement. Conventional therapies fail to mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling an organ's circadian function and are influenced by glucocorticoids. However, clock gene expression has never been investigated in AI patients.| File | Dimensione | Formato | |
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Venneri_Circadian rhythm_2018.pdf
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