Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which the dystrophin gene is mutated, resulting in dysfunctional dystrophin protein. Without dystrophin, the dystrophin-glycoprotein complex (DGC) is unstable, leading to an increase in muscle damage. Moreover, the imbalance between muscle damage and repair leads to a chronic inflammatory response and an increase in the amount of fibrosis over time. The absence of dystrophin at the sarcolemma also delocalizes and downregulates nitric oxide synthase (nNOS) and alters enzymatic antioxidant responses, leading to an increase in oxidative stress. In this review, we analyze the pathogenic role of both inflammation and oxidative stress in muscular dystrophy.

Insights into the pathogenic secondary symptoms caused by the primary loss of dystrophin / Forcina, Laura; Pelosi, Laura; Miano, Carmen; Musarò, Antonio. - In: JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY. - ISSN 2411-5142. - ELETTRONICO. - 2:4(2017), pp. 1-15. [10.3390/jfmk2040044]

Insights into the pathogenic secondary symptoms caused by the primary loss of dystrophin

Forcina, Laura;Pelosi, Laura;Miano, Carmen;Musarò, Antonio
2017

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which the dystrophin gene is mutated, resulting in dysfunctional dystrophin protein. Without dystrophin, the dystrophin-glycoprotein complex (DGC) is unstable, leading to an increase in muscle damage. Moreover, the imbalance between muscle damage and repair leads to a chronic inflammatory response and an increase in the amount of fibrosis over time. The absence of dystrophin at the sarcolemma also delocalizes and downregulates nitric oxide synthase (nNOS) and alters enzymatic antioxidant responses, leading to an increase in oxidative stress. In this review, we analyze the pathogenic role of both inflammation and oxidative stress in muscular dystrophy.
2017
duchenne muscular dystrophy; inflammation; oxidative stress; therapeutic approaches; muscle wasting
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Insights into the pathogenic secondary symptoms caused by the primary loss of dystrophin / Forcina, Laura; Pelosi, Laura; Miano, Carmen; Musarò, Antonio. - In: JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY. - ISSN 2411-5142. - ELETTRONICO. - 2:4(2017), pp. 1-15. [10.3390/jfmk2040044]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1118669
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