Neurotensin is a peptide with effects on appetite and intestinal lipid absorption. Experimental data suggest a role in glucose homeostasis, while human data is missing. Here, 20 morbidly obese subjects either underwent biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB) in a randomized fashion. Before and 1 year after surgery, anthropometric data, body composition, clinical biochemistry, insulin sensitivity by means of euglycemic hyperinsulinemic clamps (HEC) and fasting plasma proneurotensin 1–117 were analyzed. Plasma proneurotensin increased significantly more 1 year after BDP than RYGB (P = 0.028), while weight loss was comparable. After metabolic surgery, proneurotensin correlated positively with insulin sensitivity (M-value) (r = 0.55, P < 0.001), while an inverse relationship with fasting glucose, HOMA-IR and HbA1c was observed (P < 0.05 for all components). After adjustment for age and gender, proneurotensin and BMI remained independently related with delta of M-value (β = 0.46 and β = 0.51, P < 0.05, resp.). From these data we conclude that proneurotensin positively correlates with insulin sensitivity uniquely after weight loss induced by metabolic surgery in humans. BDP leads to a stronger increase in the anorexigenic peptide compared to RYGB.

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery / von Loeffelholz, Christian; Gissey, Lidia Castagneto; Schumann, Tina; Henke, Christine; Kurzbach, Anica; Struck, Joachim; Bergmann, Andreas; Hanefeld, Markolf; Schatz, Ulrike; Bornstein, Stefan R.; Casella, Giovanni; Mingrone, Geltrude; Birkenfeld, Andreas L.. - In: INTERNATIONAL JOURNAL OF OBESITY. - ISSN 0307-0565. - ELETTRONICO. - (2018), pp. 1-5. [10.1038/s41366-018-0084-3]

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

Gissey, Lidia Castagneto
Membro del Collaboration Group
;
Casella, Giovanni
Membro del Collaboration Group
;
2018

Abstract

Neurotensin is a peptide with effects on appetite and intestinal lipid absorption. Experimental data suggest a role in glucose homeostasis, while human data is missing. Here, 20 morbidly obese subjects either underwent biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB) in a randomized fashion. Before and 1 year after surgery, anthropometric data, body composition, clinical biochemistry, insulin sensitivity by means of euglycemic hyperinsulinemic clamps (HEC) and fasting plasma proneurotensin 1–117 were analyzed. Plasma proneurotensin increased significantly more 1 year after BDP than RYGB (P = 0.028), while weight loss was comparable. After metabolic surgery, proneurotensin correlated positively with insulin sensitivity (M-value) (r = 0.55, P < 0.001), while an inverse relationship with fasting glucose, HOMA-IR and HbA1c was observed (P < 0.05 for all components). After adjustment for age and gender, proneurotensin and BMI remained independently related with delta of M-value (β = 0.46 and β = 0.51, P < 0.05, resp.). From these data we conclude that proneurotensin positively correlates with insulin sensitivity uniquely after weight loss induced by metabolic surgery in humans. BDP leads to a stronger increase in the anorexigenic peptide compared to RYGB.
2018
Medicine (miscellaneous); endocrinology, diabetes and metabolism; nutrition and dietetics
01 Pubblicazione su rivista::01a Articolo in rivista
The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery / von Loeffelholz, Christian; Gissey, Lidia Castagneto; Schumann, Tina; Henke, Christine; Kurzbach, Anica; Struck, Joachim; Bergmann, Andreas; Hanefeld, Markolf; Schatz, Ulrike; Bornstein, Stefan R.; Casella, Giovanni; Mingrone, Geltrude; Birkenfeld, Andreas L.. - In: INTERNATIONAL JOURNAL OF OBESITY. - ISSN 0307-0565. - ELETTRONICO. - (2018), pp. 1-5. [10.1038/s41366-018-0084-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1118553
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