• expression in T1 NO M0 breast cancer Evaluation of Msh2, Mlhl, Brcal and Fhit protein E. Giarnieri 1, G. De Francesco 2, C. Amanti 3, B. Bucci 4, V. Catracchia 5, V. Moscaroli 6, M. Lo Russo 7, M. Giovagno@. i University of Rome "La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy; 2UniversityofRome"LaSapienza"IISchoolofMedicine, PathologyS Andrea Hospital, Rome, Italy; 3University of Rome "La Sapienza" II School of Medicine, Surgery S Andrea Hospital, Rome, Italy; 4Fatebenefratelli S Pietro Hospital, Research Center, Rome, Italy; 5University of Rome "La Sapienza"IISchoolofMedicine, SurgerySAndreaHospital, Rome,Italy; 6UniversityofRome"LaSapienza"IISchoolofMedicine, SurgerySAndrea Hospital, Rome, Italy; 7University of Rome "La Sapienza" II School of Medicine, SurgerySAndreaHospital, Rome,Italy;8UniversityofRome"La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy The development of breast cancer, as observed in other malignancies, is a multistep process in which genetic changes are required to convert normal epithelium to invasive cancer. To analyze relevant factors and their effects on neoplastic progression in T1 NO M0 breast cancer, a panel of genetic mark- ers was studied. Expression of Msh2, Mlhl, Brcal and Fhit protein were eval- S15 S 16 Poster Session I. Biology Thursday, 27 January 2005 uated by immunohistochemistry in 41 patients with T1NOM0 invasive ductal breast carcinoma. Statistically significant correlations between Msh2, Mlhl and Brcal protein expression were detected (p< 0.003 and p < 0.001, re- spectively), and association between Mlhl, Brcal and Fhit expression were observed (p < 0.048 and p < 0.01, respectively). Eight of 26 (30%) cases with <1 cm tumor size, and 10 out of 15 (67%) cases with > 1 cm to _<2 cm diameter proved negative for Msh2 showing a statistical significance for p < 0.028. Twelve of 26 (42%) cases with _<1 cm tumor size, and 12 of 15 (80%) cases with > 1 cm to _<2 cm diameter proved negative immunoreactivity for Mlhl with a statistical realationship (p < 0.035). A relationship between
Evaluation of Msh2,Mih1,Brca1,and Fhit protein expression in T1N0M0 breast cancer / Giarnieri, Enrico; DE FRANCESCO, G; Amanti, Claudio; Bucci, B; Catracchia, V.. - In: THE BREAST. - ISSN 0960-9776. - STAMPA. - 14:(2005), pp. 15-15.
Evaluation of Msh2,Mih1,Brca1,and Fhit protein expression in T1N0M0 breast cancer
GIARNIERI, Enrico;AMANTI, Claudio;
2005
Abstract
• expression in T1 NO M0 breast cancer Evaluation of Msh2, Mlhl, Brcal and Fhit protein E. Giarnieri 1, G. De Francesco 2, C. Amanti 3, B. Bucci 4, V. Catracchia 5, V. Moscaroli 6, M. Lo Russo 7, M. Giovagno@. i University of Rome "La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy; 2UniversityofRome"LaSapienza"IISchoolofMedicine, PathologyS Andrea Hospital, Rome, Italy; 3University of Rome "La Sapienza" II School of Medicine, Surgery S Andrea Hospital, Rome, Italy; 4Fatebenefratelli S Pietro Hospital, Research Center, Rome, Italy; 5University of Rome "La Sapienza"IISchoolofMedicine, SurgerySAndreaHospital, Rome,Italy; 6UniversityofRome"LaSapienza"IISchoolofMedicine, SurgerySAndrea Hospital, Rome, Italy; 7University of Rome "La Sapienza" II School of Medicine, SurgerySAndreaHospital, Rome,Italy;8UniversityofRome"La Sapienza"IISchoolofMedicine, PathologySAndreaHospital, Rome,Italy The development of breast cancer, as observed in other malignancies, is a multistep process in which genetic changes are required to convert normal epithelium to invasive cancer. To analyze relevant factors and their effects on neoplastic progression in T1 NO M0 breast cancer, a panel of genetic mark- ers was studied. Expression of Msh2, Mlhl, Brcal and Fhit protein were eval- S15 S 16 Poster Session I. Biology Thursday, 27 January 2005 uated by immunohistochemistry in 41 patients with T1NOM0 invasive ductal breast carcinoma. Statistically significant correlations between Msh2, Mlhl and Brcal protein expression were detected (p< 0.003 and p < 0.001, re- spectively), and association between Mlhl, Brcal and Fhit expression were observed (p < 0.048 and p < 0.01, respectively). Eight of 26 (30%) cases with <1 cm tumor size, and 10 out of 15 (67%) cases with > 1 cm to _<2 cm diameter proved negative for Msh2 showing a statistical significance for p < 0.028. Twelve of 26 (42%) cases with _<1 cm tumor size, and 12 of 15 (80%) cases with > 1 cm to _<2 cm diameter proved negative immunoreactivity for Mlhl with a statistical realationship (p < 0.035). A relationship betweenI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
