DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge of the dynamic nature of DNA epigenome landscape in mammals, and propose putative molecular mechanisms for aging-associated DNA epigenetic changes. Specifically, we describe age-related variations of methylcytosine and its oxidative derivatives in relation to the dynamics of chromatin structure, histone post-translational modifications and their modulators.Finally, we are proposing a conceptual framework that could explain the complex nature of the effects of age on DNA methylation patterns. This combines the accumulation of DNA methylation noise and also all of the predictable, site-specific DNA methylation changes.Gathering information in this area would pave the way for future investigation aimed at establishing a possible causative role of epigenetic mechanisms in aging.

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? / Ciccarone, Fabio; Tagliatesta, Stefano; Caiafa, Paola; Zampieri, Michele. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - ELETTRONICO. - 174:(2018), pp. 3-17. [10.1016/j.mad.2017.12.002]

DNA methylation dynamics in aging: How far are we from understanding the mechanisms?

Ciccarone, Fabio
Primo
Conceptualization
;
Tagliatesta, Stefano
Secondo
Writing – Original Draft Preparation
;
Caiafa, Paola
Writing – Review & Editing
;
Zampieri, Michele
Ultimo
Conceptualization
2018

Abstract

DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge of the dynamic nature of DNA epigenome landscape in mammals, and propose putative molecular mechanisms for aging-associated DNA epigenetic changes. Specifically, we describe age-related variations of methylcytosine and its oxidative derivatives in relation to the dynamics of chromatin structure, histone post-translational modifications and their modulators.Finally, we are proposing a conceptual framework that could explain the complex nature of the effects of age on DNA methylation patterns. This combines the accumulation of DNA methylation noise and also all of the predictable, site-specific DNA methylation changes.Gathering information in this area would pave the way for future investigation aimed at establishing a possible causative role of epigenetic mechanisms in aging.
2018
Aging; Chromatin; DNA demethylation; DNA methylation; Histones; Aging; Developmental Biology
01 Pubblicazione su rivista::01a Articolo in rivista
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? / Ciccarone, Fabio; Tagliatesta, Stefano; Caiafa, Paola; Zampieri, Michele. - In: MECHANISMS OF AGEING AND DEVELOPMENT. - ISSN 0047-6374. - ELETTRONICO. - 174:(2018), pp. 3-17. [10.1016/j.mad.2017.12.002]
File allegati a questo prodotto
File Dimensione Formato  
Ciccarone_DNA_2017.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Creative commons
Dimensione 610.23 kB
Formato Adobe PDF
610.23 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1117319
Citazioni
  • ???jsp.display-item.citation.pmc??? 52
  • Scopus 101
  • ???jsp.display-item.citation.isi??? 98
social impact