The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.

Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1 / Ciarlo, Laura; Vona, Rosa; Manganelli, Valeria; Gambardella, Lucrezia; Raggi, Carla; Marconi, Matteo; Malorni, Walter; Sorice, Maurizio; Garofalo, Tina; Matarrese, Paola. - In: ONCOTARGET. - ISSN 1949-2553. - 9:27(2018), pp. 18869-18884. [10.18632/oncotarget.24792]

Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1

Manganelli, Valeria;Sorice, Maurizio;Garofalo, Tina;
2018

Abstract

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid "rafts" in mitochondrial morphogenetic changes and their homeostasis.
2018
Apoptosis; Fusion; Lipid rafts; Mitochondria; Reactive oxygen species; Oncology
01 Pubblicazione su rivista::01a Articolo in rivista
Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1 / Ciarlo, Laura; Vona, Rosa; Manganelli, Valeria; Gambardella, Lucrezia; Raggi, Carla; Marconi, Matteo; Malorni, Walter; Sorice, Maurizio; Garofalo, Tina; Matarrese, Paola. - In: ONCOTARGET. - ISSN 1949-2553. - 9:27(2018), pp. 18869-18884. [10.18632/oncotarget.24792]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1115410
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