AIM To perform a systematic review and meta-analysis on donor-to-recipient gender mismatch as a risk factor for post-transplant graft loss. METHODS A systematic literature search was performed using PubMed, Cochrane Library database and EMBASE. The primary outcome was graft loss after liver transplantation. Odds ratios and 95% confidence intervals were calculated to compare the pooled data between groups with different donor-to-recipient gender matches. Three analyses were done considering (1) gender mismatches (F-M and M-F) vs matches (M-M and F-F); (2) Female-to-Male mismatch vs other matches; and (3) Male-to-Female mismatch vs other matches. RESULTS A total of 7 articles were analysed. Gender mismatch (M-F and F-M) was associated with a significant increase of graft loss respect to match (M-M and F-F) (OR: 1.30; 95%CI: 1.13-1.50; P < 0.001). When F-M mismatch was specifically investigated, it confirmed its detrimental role in terms of graft survival (OR: 1.83; 95%CI: 1.20-2.80; P = 0.005). M-F mismatch failed to present a significant role (OR: 1.09; 95%CI: 0.73-1.62; P = 0.68). CONCLUSION Gender mismatch is a risk factor for poor graft survival after liver transplantation. Female-to-male mismatch represents the worst combination. More studies are needed with the intent to better clarify the reasons for these results.

Donor-to-recipient gender match in liver transplantation. A systematic review and meta-analysis / Giovanardi, Francesco; Melandro, Fabio; Laureiro, Zoe Larghi; Merli, Manuela; Lattanzi, Barbara; Hassan, Redan; Rossi, Massimo; Mennini, Gianluca; Lai, Quirino. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - STAMPA. - 24:20(2018), pp. 2203-2210. [10.3748/wjg.v24.i20.2203]

Donor-to-recipient gender match in liver transplantation. A systematic review and meta-analysis

Giovanardi, Francesco;Melandro, Fabio;Laureiro, Zoe Larghi;Merli, Manuela;Lattanzi, Barbara;Hassan, Redan;Rossi, Massimo;Mennini, Gianluca;Lai, Quirino
2018

Abstract

AIM To perform a systematic review and meta-analysis on donor-to-recipient gender mismatch as a risk factor for post-transplant graft loss. METHODS A systematic literature search was performed using PubMed, Cochrane Library database and EMBASE. The primary outcome was graft loss after liver transplantation. Odds ratios and 95% confidence intervals were calculated to compare the pooled data between groups with different donor-to-recipient gender matches. Three analyses were done considering (1) gender mismatches (F-M and M-F) vs matches (M-M and F-F); (2) Female-to-Male mismatch vs other matches; and (3) Male-to-Female mismatch vs other matches. RESULTS A total of 7 articles were analysed. Gender mismatch (M-F and F-M) was associated with a significant increase of graft loss respect to match (M-M and F-F) (OR: 1.30; 95%CI: 1.13-1.50; P < 0.001). When F-M mismatch was specifically investigated, it confirmed its detrimental role in terms of graft survival (OR: 1.83; 95%CI: 1.20-2.80; P = 0.005). M-F mismatch failed to present a significant role (OR: 1.09; 95%CI: 0.73-1.62; P = 0.68). CONCLUSION Gender mismatch is a risk factor for poor graft survival after liver transplantation. Female-to-male mismatch represents the worst combination. More studies are needed with the intent to better clarify the reasons for these results.
2018
Donor-to-recipient match; Female-to-male mismatch; Gender; Graft survival; Liver transplantation; Gastroenterology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Donor-to-recipient gender match in liver transplantation. A systematic review and meta-analysis / Giovanardi, Francesco; Melandro, Fabio; Laureiro, Zoe Larghi; Merli, Manuela; Lattanzi, Barbara; Hassan, Redan; Rossi, Massimo; Mennini, Gianluca; Lai, Quirino. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - STAMPA. - 24:20(2018), pp. 2203-2210. [10.3748/wjg.v24.i20.2203]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1115233
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