In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine,with DNA G-quadruplex structureswere reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.

Natural aromatic compounds as scaffolds to develop selective G-quadruplex ligands. From previously reported berberine derivatives to new palmatine analogues / Franceschin, Marco; Cianni, Lorenzo; Pitorri, Massimo; Micheli, Emanuela; Cacchione, Stefano; Frezza, Claudio; Serafini, Mauro; Hu, Ming-Hao; Su, Huafi; Huang, Zhishu; Gu, Lianquan; Bianco, Armandodoriano. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 23:1423(2018), pp. 1-14. [10.3390/molecules23061423]

Natural aromatic compounds as scaffolds to develop selective G-quadruplex ligands. From previously reported berberine derivatives to new palmatine analogues

Marco Franceschin
;
Emanuela Micheli;Stefano Cacchione;Claudio Frezza
;
Mauro Serafini;Armandodoriano Bianco
2018

Abstract

In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine,with DNA G-quadruplex structureswere reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.
2018
G-quadruplex DNA; interactions; berberine and palmatine derivatives; NMR; FRET and MST assays
01 Pubblicazione su rivista::01a Articolo in rivista
Natural aromatic compounds as scaffolds to develop selective G-quadruplex ligands. From previously reported berberine derivatives to new palmatine analogues / Franceschin, Marco; Cianni, Lorenzo; Pitorri, Massimo; Micheli, Emanuela; Cacchione, Stefano; Frezza, Claudio; Serafini, Mauro; Hu, Ming-Hao; Su, Huafi; Huang, Zhishu; Gu, Lianquan; Bianco, Armandodoriano. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 23:1423(2018), pp. 1-14. [10.3390/molecules23061423]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1115082
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