Starting from C-CF3-substituted aldimines, trifluoromethyl beta-lactams were obtained as only products in the reaction with some α-bromo esters in the presence of activated zinc dust. Different solvents, molar ratios, and temperature were tested to determine the best reaction conditions that led only to desired cyclic compounds. The influence of another ester group on the aldimine chain and the reaction diastereoselectivity were also considered.
Selective synthesis of trifluoromethyl β-lactams by a Zn-promoted 2-bromo ester addition on C-CF3 –substituted aldimines / Laura, Trulli; Venanzio, Raglione; Stefania, Fioravanti. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1099-0690. - STAMPA. - 22(2018). [10.1002/ejoc.201800168]
Selective synthesis of trifluoromethyl β-lactams by a Zn-promoted 2-bromo ester addition on C-CF3 –substituted aldimines
Laura Trulli;RAGLIONE, VENANZIO;Stefania Fioravanti
2018
Abstract
Starting from C-CF3-substituted aldimines, trifluoromethyl beta-lactams were obtained as only products in the reaction with some α-bromo esters in the presence of activated zinc dust. Different solvents, molar ratios, and temperature were tested to determine the best reaction conditions that led only to desired cyclic compounds. The influence of another ester group on the aldimine chain and the reaction diastereoselectivity were also considered.| File | Dimensione | Formato | |
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