This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.
DISRUPTION OF THE IMMUNOPEPTIDERGIC NETWORK IN DIETARY MIGRAINE / Martelletti, Paolo; Giuseppe, Stirparo; Rinaldi, Cristina; Frati, Luigi; Giacovazzo, Mario. - In: HEADACHE. - ISSN 0017-8748. - STAMPA. - 33:10(1993), pp. 524-527. [10.1111/j.1526-4610.1993.hed3310524.x]
DISRUPTION OF THE IMMUNOPEPTIDERGIC NETWORK IN DIETARY MIGRAINE
MARTELLETTI, Paolo;RINALDI, Cristina;FRATI, Luigi;GIACOVAZZO, Mario
1993
Abstract
This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma, GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, considering the close links between interleukins and other cytokines and the neuro-mediators of pain, such as histamine and 5-HT.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
