This review article focuses on the many metabolic actions of insulin at the level of muscle, liver and adipose tissue. In terms of pathogenetic mechanisms, the condition of insulin resistance is complex, as multiple genetic and environmental factors, among which an increasingly sedentary lifestyle associated with high-fat diet, mutually interact according to variable patterns in time in any given individual. It is well recognized that obesity (in particular abdominal obesity) favours the development of insulin resistance. Here we evaluate the impact of obesity and ectopic fat accumulation (visceral and hepatic) on insulin resistance at the level of different target organs, i.e., muscle, liver and adipose tissue. The roles of the gut and the liver, in particular of bile acids and gut microflora, are also discussed as possible determinants of energy balance and glucose metabolism. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Insulin resistance, adipose depots and gut: Interactions and pathological implications / Amalia, Gastaldelli; Andrea, Natali; Roberto, Vettor; GINANNI CORRADINI, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 42:5(2010), pp. 310-319. [10.1016/j.dld.2010.01.013]

Insulin resistance, adipose depots and gut: Interactions and pathological implications

GINANNI CORRADINI, Stefano
2010

Abstract

This review article focuses on the many metabolic actions of insulin at the level of muscle, liver and adipose tissue. In terms of pathogenetic mechanisms, the condition of insulin resistance is complex, as multiple genetic and environmental factors, among which an increasingly sedentary lifestyle associated with high-fat diet, mutually interact according to variable patterns in time in any given individual. It is well recognized that obesity (in particular abdominal obesity) favours the development of insulin resistance. Here we evaluate the impact of obesity and ectopic fat accumulation (visceral and hepatic) on insulin resistance at the level of different target organs, i.e., muscle, liver and adipose tissue. The roles of the gut and the liver, in particular of bile acids and gut microflora, are also discussed as possible determinants of energy balance and glucose metabolism. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
2010
adipose tissue; gut microbiota; hepatic fat; nafld; obesity
01 Pubblicazione su rivista::01a Articolo in rivista
Insulin resistance, adipose depots and gut: Interactions and pathological implications / Amalia, Gastaldelli; Andrea, Natali; Roberto, Vettor; GINANNI CORRADINI, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 42:5(2010), pp. 310-319. [10.1016/j.dld.2010.01.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/111185
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