Senile purpura (SP), characterized by purpuric macules and patches on photoaged skin of the extremities, belongs to the earliest stage of dermatoporosis, a progressive condition of the elderly resulting in skin fragility and subsequent bleeding, ulceration, delayed wound healing and deep dissecting hematomas that may require hospitalization and surgical treatment. The haemorrhage observed in SP has been related to impaired mechanical protection by the dermal extracellular matrix, leading to vessel rupture after minor traumas. Despite microvasculature changes in photoaged skin are recognized, these have not been investigated in SP. We quantitatively assessed dermal microvasculature density and thickness of dermal microvascular basement membrane (MBM) collagen IV, in consecutive SP patients.
Involvement of dermal microvascular basement membrane in senile purpura: quantitative immunohistochemical study / Borroni, R. G.; Grassi, S.; Concardi, M.; Agozzino, M.; Caspani, C.; Giordano, C.; Vignini, M.; Arbustini, E.. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 30:10(2016), pp. e63-e65. [10.1111/jdv.13304]
Involvement of dermal microvascular basement membrane in senile purpura: quantitative immunohistochemical study
Grassi, S.;
2016
Abstract
Senile purpura (SP), characterized by purpuric macules and patches on photoaged skin of the extremities, belongs to the earliest stage of dermatoporosis, a progressive condition of the elderly resulting in skin fragility and subsequent bleeding, ulceration, delayed wound healing and deep dissecting hematomas that may require hospitalization and surgical treatment. The haemorrhage observed in SP has been related to impaired mechanical protection by the dermal extracellular matrix, leading to vessel rupture after minor traumas. Despite microvasculature changes in photoaged skin are recognized, these have not been investigated in SP. We quantitatively assessed dermal microvasculature density and thickness of dermal microvascular basement membrane (MBM) collagen IV, in consecutive SP patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
