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BACKGROUND: Previous studies have reported that a consistent proportion of patients with Essential Tremor may have psychiatric disorders but it is unclear whether these disorders are increased in frequency as compared to healthy subjects. METHODS: In a case-control study, we adopted the structured interviews for DSM-IV, SCID-I and SCID-II, to investigate psychiatric and personality disorders in 37 ET patients and 34 healthy subjects. As cognitive changes in ET may be a confounding factor we enrolled patients and healthy control subjects without cognitive dysfunction. RESULTS: SCID-I showed that Axis-I psychiatric disorders, mainly depressive disorders, were more frequent in ET patients (20 of 37; 54%) than in healthy subjects (8 of 34; 22%) (p < 0.01). Depressive disorders were more frequent in patients with a family history of ET (p < 0.05) in comparison to patients without a family history. SCID-II disclosed that the frequency of personality disorders was similar in patients with ET and healthy subjects. CONCLUSION: Psychiatric disorders may be associated to the neurological manifestations of ET. Copyright © 2012 Elsevier Ltd. All rights reserved.

Psychiatric disorders in patients with essential tremor / Fabbrini, Giovanni; Berardelli, Isabella; Falla, Marika; Moretti, Germana; Pasquini, Massimo; Altieri, Marta; Defazio, Giovanni; Biondi, Massimo; Berardelli, Alfredo. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1353-8020. - STAMPA. - 18:8(2012), pp. 971-973. [10.1016/j.parkreldis.2012.05.005]

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