Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field. © 2007 New York Academy of Sciences.
Evaluation of current methods for the measurement of serum anti-double-stranded DNA antibodies / A., Ghirardello; D., Villalta; G., Morozzi; A., Afeltra; M., Galeazzi; R., Mathieu Gerli; P. L., Meroni; P., Migliorini; A., Radice; Riccieri, Valeria; A., Ruffatti; G. D., Sebastiani; A., Tincani; A., Doria; Firma, Group. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - 1109:1(2007), pp. 401-406. [10.1196/annals.1398.045]
Evaluation of current methods for the measurement of serum anti-double-stranded DNA antibodies
RICCIERI, Valeria;
2007
Abstract
Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field. © 2007 New York Academy of Sciences.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
