INTRODUCTION: Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually. Chronic infection can result in cirrhosis and hepatocellular carcinoma. EXPLANATION: Epidemiological studies have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC), mainly through chronic inflammation, cell deaths, and proliferation. Despite the new direct-acting antiviral drugs (DAA's) being able to clear the HCV, HCC recurrence rate in these patients is still observed. CONCLUSION: In this review we highlighted some aspects that could be involved in the onset of HCV-induced HCC such as immune system, viral factors and host genetics factors.Moreover, we focused on some of the last reports about the effects of DAA's on the HCV clearance and their potential implications in HCC recurrence.

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals / Schietroma, Ivan; Scheri, Giuseppe Corano; Pinacchio, Claudia; Statzu, Maura; Petruzziello, Arnolfo; Vullo, Vincenzo. - In: THE OPEN VIROLOGY JOURNAL. - ISSN 1874-3579. - ELETTRONICO. - 12:Suppl-1, M2(2018), pp. 16-25. [10.2174/1874357901812010016]

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals

Schietroma, Ivan;Scheri, Giuseppe Corano
;
Pinacchio, Claudia;Statzu, Maura;Vullo, Vincenzo
2018

Abstract

INTRODUCTION: Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually. Chronic infection can result in cirrhosis and hepatocellular carcinoma. EXPLANATION: Epidemiological studies have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC), mainly through chronic inflammation, cell deaths, and proliferation. Despite the new direct-acting antiviral drugs (DAA's) being able to clear the HCV, HCC recurrence rate in these patients is still observed. CONCLUSION: In this review we highlighted some aspects that could be involved in the onset of HCV-induced HCC such as immune system, viral factors and host genetics factors.Moreover, we focused on some of the last reports about the effects of DAA's on the HCV clearance and their potential implications in HCC recurrence.
2018
chronic infection; daa’s; hcc; hcv; immunity; viral factors
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals / Schietroma, Ivan; Scheri, Giuseppe Corano; Pinacchio, Claudia; Statzu, Maura; Petruzziello, Arnolfo; Vullo, Vincenzo. - In: THE OPEN VIROLOGY JOURNAL. - ISSN 1874-3579. - ELETTRONICO. - 12:Suppl-1, M2(2018), pp. 16-25. [10.2174/1874357901812010016]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1094312
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