To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor. We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women. Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 +/- 22.5 pg/mL and 182.7 +/- 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 +/- 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 +/- 26.8 pg/mL). Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.

Amniotic fluid concentrations of adrenomedullin / Marinoni, Emanuela; DI IORIO, Romolo; Letizia, Claudio; B., Villaccio; A., Alberini; Cosmi, Ermelando. - In: OBSTETRICS AND GYNECOLOGY. - ISSN 0029-7844. - STAMPA. - 93:6(1999), pp. 964-967. [10.1016/s0029-7844(98)00551-1]

Amniotic fluid concentrations of adrenomedullin.

MARINONI, EMANUELA;DI IORIO, Romolo;LETIZIA, Claudio;COSMI, Ermelando
1999

Abstract

To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor. We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocentesis from 36 women with clinical diagnosis of preterm labor or preterm premature rupture of membranes (PROM) and from 18 normal pregnant women. Amniotic fluid from cases of PROM and failure to respond to tocolysis were associated significantly with higher amniotic fluid adrenomedullin concentrations (177.0 +/- 22.5 pg/mL and 182.7 +/- 22.0 pg/mL, respectively, P < .01) than that from uncomplicated pregnancies (101.2 +/- 28.1 pg/mL) or preterm labor responsive to tocolysis (102.3 +/- 26.8 pg/mL). Amniotic fluid adrenomedullin is higher than normal in cases of PROM and preterm labor unresponsive to tocolysis, perhaps indicating enhanced synthesis from placenta or fetal membranes being stimulated by bacterial products.
1999
01 Pubblicazione su rivista::01a Articolo in rivista
Amniotic fluid concentrations of adrenomedullin / Marinoni, Emanuela; DI IORIO, Romolo; Letizia, Claudio; B., Villaccio; A., Alberini; Cosmi, Ermelando. - In: OBSTETRICS AND GYNECOLOGY. - ISSN 0029-7844. - STAMPA. - 93:6(1999), pp. 964-967. [10.1016/s0029-7844(98)00551-1]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/109342
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 21
social impact