Pathologically impaired fear extinction is thought to contribute to the development and persistence of psychiatric disorders, such as post-traumatic stress disorder (PTSD). PTSD prevalence is twice as high in women as in men, with treatment efficacy also reflecting sex-differences. The mechanisms underlying sex-differences in fear coping responses may involve the endocannabinoid (eCB) system. Thus, the principal objective of this study was to investigate the role of the endocannabinoid anandamide (AEA) in regulating fear memory extinction, as well as fear coping mechanisms, in male and female rats.
Sex-specific effects of the endocannabinoid anandamide hydrolysis inhibition on fear memory dynamics / Nastase, Andrei S.; Santori, Alessia; Morena, Maria; Hill, Matthew N.. - STAMPA. - (2017). (Intervento presentato al convegno HBI Summer Student Symposium 2017 tenutosi a Calgary, Alberta (Canada)).
Sex-specific effects of the endocannabinoid anandamide hydrolysis inhibition on fear memory dynamics
Santori, Alessia;
2017
Abstract
Pathologically impaired fear extinction is thought to contribute to the development and persistence of psychiatric disorders, such as post-traumatic stress disorder (PTSD). PTSD prevalence is twice as high in women as in men, with treatment efficacy also reflecting sex-differences. The mechanisms underlying sex-differences in fear coping responses may involve the endocannabinoid (eCB) system. Thus, the principal objective of this study was to investigate the role of the endocannabinoid anandamide (AEA) in regulating fear memory extinction, as well as fear coping mechanisms, in male and female rats.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
